医学信息
醫學信息
의학신식
Medical Information
2015年
44期
103-104
,共2页
2型糖尿病%糖尿病肾病%尿蛋白阴性%高血压%高胆固醇
2型糖尿病%糖尿病腎病%尿蛋白陰性%高血壓%高膽固醇
2형당뇨병%당뇨병신병%뇨단백음성%고혈압%고담고순
Type 2 diabetes%Diabetic nephropathy%Urinary protein negative%Hypertension%High cholesterol
目的探讨2型糖尿病患者中尿蛋白阴性糖尿病肾病危险因素及可能发病机制；方法将入选的97例糖尿病肾病患者按尿微量白蛋白排泄量分为尿蛋白阴性组（57例）、尿蛋白阳性组（40例），以同期非糖尿病肾病患者（50例）作为对照组，对3组的临床资料进行比较分析，并利用Person直线相关、多元逐步回归分析尿蛋白阴性糖尿病肾病估算肾小球滤过率（eGFR）的影响因素；结果尿蛋白阴性组总胆固醇（TC）浓度、高血压患病率明显高于对照组（<0.05），而糖尿病病程、糖化血红蛋白（HbA1c）水平较对照组差异无统计学意义。尿蛋白阴性组糖尿病病程显著短于尿蛋白阳性组（<0.01），糖尿病视网膜病变（DR）发生率、HbA1c水平明显低于尿蛋白阳性组（<0.05）。Person直线相关分析显示尿蛋白阴性糖尿病肾病患者eGFR水平与病程、TC、Apo-B存在负相关关系（<0.01）。多元逐步回归分析显示院TC是影响尿蛋白阴性糖尿病肾病eGFR的主要因素（回归系数为-1.802，<0.05）；结论尿蛋白阴性糖尿病肾病的发生、发展与高血压、高胆固醇有一定关系，与血糖关系不大。控制血压、血脂在防治尿蛋白阴性糖尿病肾病中有重要作用。
目的探討2型糖尿病患者中尿蛋白陰性糖尿病腎病危險因素及可能髮病機製；方法將入選的97例糖尿病腎病患者按尿微量白蛋白排洩量分為尿蛋白陰性組（57例）、尿蛋白暘性組（40例），以同期非糖尿病腎病患者（50例）作為對照組，對3組的臨床資料進行比較分析，併利用Person直線相關、多元逐步迴歸分析尿蛋白陰性糖尿病腎病估算腎小毬濾過率（eGFR）的影響因素；結果尿蛋白陰性組總膽固醇（TC）濃度、高血壓患病率明顯高于對照組（<0.05），而糖尿病病程、糖化血紅蛋白（HbA1c）水平較對照組差異無統計學意義。尿蛋白陰性組糖尿病病程顯著短于尿蛋白暘性組（<0.01），糖尿病視網膜病變（DR）髮生率、HbA1c水平明顯低于尿蛋白暘性組（<0.05）。Person直線相關分析顯示尿蛋白陰性糖尿病腎病患者eGFR水平與病程、TC、Apo-B存在負相關關繫（<0.01）。多元逐步迴歸分析顯示院TC是影響尿蛋白陰性糖尿病腎病eGFR的主要因素（迴歸繫數為-1.802，<0.05）；結論尿蛋白陰性糖尿病腎病的髮生、髮展與高血壓、高膽固醇有一定關繫，與血糖關繫不大。控製血壓、血脂在防治尿蛋白陰性糖尿病腎病中有重要作用。
목적탐토2형당뇨병환자중뇨단백음성당뇨병신병위험인소급가능발병궤제；방법장입선적97례당뇨병신병환자안뇨미량백단백배설량분위뇨단백음성조（57례）、뇨단백양성조（40례），이동기비당뇨병신병환자（50례）작위대조조，대3조적림상자료진행비교분석，병이용Person직선상관、다원축보회귀분석뇨단백음성당뇨병신병고산신소구려과솔（eGFR）적영향인소；결과뇨단백음성조총담고순（TC）농도、고혈압환병솔명현고우대조조（<0.05），이당뇨병병정、당화혈홍단백（HbA1c）수평교대조조차이무통계학의의。뇨단백음성조당뇨병병정현저단우뇨단백양성조（<0.01），당뇨병시망막병변（DR）발생솔、HbA1c수평명현저우뇨단백양성조（<0.05）。Person직선상관분석현시뇨단백음성당뇨병신병환자eGFR수평여병정、TC、Apo-B존재부상관관계（<0.01）。다원축보회귀분석현시원TC시영향뇨단백음성당뇨병신병eGFR적주요인소（회귀계수위-1.802，<0.05）；결론뇨단백음성당뇨병신병적발생、발전여고혈압、고담고순유일정관계，여혈당관계불대。공제혈압、혈지재방치뇨단백음성당뇨병신병중유중요작용。
Objective To investigate risk factors and possible pathogenesis of diabetic nephropathy with urinary protein negative in patients of type 2 diabetes mel itus. Methods Patients with diabetic nephropathy were divided into negative group and positive group according to urinary albumin excretion,and patients of non-diabetic nephropathy in the same period as a control group.Clinical data were comparative analyzed,and influencing factors of estimated glomerular filtration rate (eGFR) in diabetic nephropathy with urine Protein negative were analyzed by person-related analysis and multiple regression analysis. Results Concentration of total cholesterol (TC) and prevalence of hypertension were significantly higher in urinary protein negative group than in the control group ( <0.05).Duration of diabetes and glycosylated hemoglobin (HbA1c) levels were not statistical y significant compared with the control group. Duration of diabetes was significantly shorter in urinary protein negative group than in urinary protein positive group (P <0.01). Incidence of diabetic retinopathy (DR) and HbA1c levels were significantly lower in urinary protein negative group than in urinary protein positive group ( <0.05). Person linear cor elation analysis showed that eGFR was negatively cor elated with duration ,TC and Apo-B in patients of diabetic nephropathy with urinary Protein negative ( <0.01). Multiple regression analysis showed that TC was a main factor af ecting eGFR levels in diabetic nephropathy with urine protein negative (regression coef icient was-1.802, <0.05). Conclusion Occur ence and development of diabetic nephropathy with urinary protein negative had a certain relationship with hypertension and high cholesterol, lit le to do with blood glucose. Control of blood pressure and blood lipids played an important role in the prevention and treatment of diabetic nephropathy with urinary protein negative.
