CAJ | 학술논문

目的分析非小细胞肺癌(NSCLC)患者贫血发生的相关因素及其对预后的影响.方法回顾性分析河北医科大学附属第四医院2008年1月至2012年11月收治的首次住院的473例NSCLC患者的临床资料.结果 473例NSCLC患者中,贫血患者共273例,贫血发生率为57.72％;贫血发生率在不同年龄(x2=3.459,P=0.039)、清蛋白水平(x2=70.648,P=0.000)、功能状态(PS)评分(x2=10.222,P=0.010)、近期是否行手术(x 2=4.956,P=0.022)及近期是否化疗(x2=3.627,P=0.037)等因素中差异均有统计学意义.经多因素分析,低蛋白血症是贫血发生的独立危险冈素(P＜0.05).贫血组的总生存时间短于非贫血组(中位数分别为15、17个月,P＜ 0.05).结论低蛋白血症是NSCLC患者贫血发生的独立危险因素.贫血的出现是NSCLC患者生存期缩短的预后指标,是NSCLC患者预后的独立因素.
목적 분석비소세포폐암(NSCLC)환자빈혈발생적상관인소급기대예후적영향.방법 회고성분석하북의과대학부속제사의원2008년1월지2012년11월수치적수차주원적473례NSCLC환자적림상자료.결과 473례NSCLC환자중,빈혈환자공273례,빈혈발생솔위57.72％;빈혈발생솔재불동년령(x2=3.459,P=0.039)、청단백수평(x2=70.648,P=0.000)、공능상태(PS)평분(x2=10.222,P=0.010)、근기시부행수술(x 2=4.956,P=0.022)급근기시부화료(x2=3.627,P=0.037)등인소중차이균유통계학의의.경다인소분석,저단백혈증시빈혈발생적독립위험강소(P＜0.05).빈혈조적총생존시간단우비빈혈조(중위수분별위15、17개월,P＜ 0.05).결론 저단백혈증시NSCLC환자빈혈발생적독립위험인소.빈혈적출현시NSCLC환자생존기축단적예후지표,시NSCLC환자예후적독립인소.
Objective To analyze the correlative factors of anemia in patients with non-small-cell lung cancer (NSCLC), and to explore the impact of anemia on prognosis.Methods The clinical data of 473 patients with NSCLC treated at the first time from January 2008 to November 2012 in the Fourth Hospital of Hebei Medical University were analyzed retrospectively.Results There were 273 patients (57.72 ％) with anemia.Anemia occurred in different age (x2 =3.459, P =3.459), different albumin level (x2 =70.648, P =70.648), different PS score (x2 =10.222, P =10.222), whether recent surgery (x2 =4.956, P =4.956), whether recent chemotherapy (x2 =3.627, P =0.037), and other factors.By multiple factors analysis, hypoalbuminemia was an independent risk factor for anemia (P ＜ 0.05).The median OS of the anemia patients was shorter than that of the patients without anemia (15 months vs 17 months, P ＜ 0.05).Conclusions Hypoalbuminemia is the independent risk factor for emergence of anemia.Anemia is the prognosis indicator of shorten survival period, which is an independent factor of prognosis in the NSCLC.