肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
Cancer Research and Clinic
2015年
10期
694-697,702
,共5页
由卫芝%王玉桂%焦盈盈%赵新蕊%李少丛
由衛芝%王玉桂%焦盈盈%趙新蕊%李少叢
유위지%왕옥계%초영영%조신예%리소총
人乳头瘤病毒%液基细胞学%子宫颈肿瘤%筛查%流行病学
人乳頭瘤病毒%液基細胞學%子宮頸腫瘤%篩查%流行病學
인유두류병독%액기세포학%자궁경종류%사사%류행병학
Human papillomavirus%Liquid-based cytology test%Uterine cervical neoplasms%Screenning%Epidemiology
目的 了解山东省聊城市子宫颈细胞学不同病理状态人群中高危型人乳头瘤病毒(HPV)感染状况及常见基因型,评价高危型HPV检测的应用价值.方法 对山东省聊城市常住人口中18～70岁已婚或有性生活女性于2013年1月至2014年1月进行子宫颈液基细胞学(TCT)筛查,筛查人数19 707人.筛查结果阳性837例,召回785例,采用高危型HPV流式细胞术荧光杂交xMAP技术进行分型检测,年龄21 ～ 65岁.对资料进行比较及描述性分析.结果 785例女性中,TCT诊断为意义不明的不典型鳞状上皮(ASCUS)及意义不明的不典型腺上皮(AGCUS) 478例,低度鳞状上皮内病变(LISL) 175例,高度鳞状上皮内病变(HSIL) 127例,鳞状细胞癌(SCC)及腺癌(ACC)5例,高危型HPV感染率分别为50.2％(240/478)、77.1％(135/175)、89.0％(113/127)、100.0％(5/5).高危型HPV感染阳性共493例,感染率为62.8％(493/785).26 ～ 30岁和51～55岁年龄组感染率较高,分别为87.7 ％(71/81)、79.7％(51/64).＞55岁年龄组感染率低,为28.6％(14/54).高危型HPV感染阳性者中,前5种常见的高危型别按阳性率递减依次为HPV16(21.5％,169/785)、HPV52(12.2％,96/785)、HPV58(9.8％,77/785)、HPV33(9.7％,76/785)、HPV18(7.5％,59/785).单型高危型HPV感染率为45.0％(353/785),多型高危型HPV感染率为17.8％(140/785).其中2型感染98例,3型感染37例,4型感染2例,5型感染2例,6型感染1例.结论 与单纯TCT筛查相比,高危型HPV检测是子宫颈癌机会性筛查的有效手段.HPV16、52、58、33、18型在山东省聊城市子宫颈细胞学异常患者中感染率较高,多型感染增加患病风险,该区域高风险人群年龄多集中在26 ～ 30岁、51～ 55岁,需重视该年龄段人群的筛查及随访.
目的 瞭解山東省聊城市子宮頸細胞學不同病理狀態人群中高危型人乳頭瘤病毒(HPV)感染狀況及常見基因型,評價高危型HPV檢測的應用價值.方法 對山東省聊城市常住人口中18～70歲已婚或有性生活女性于2013年1月至2014年1月進行子宮頸液基細胞學(TCT)篩查,篩查人數19 707人.篩查結果暘性837例,召迴785例,採用高危型HPV流式細胞術熒光雜交xMAP技術進行分型檢測,年齡21 ～ 65歲.對資料進行比較及描述性分析.結果 785例女性中,TCT診斷為意義不明的不典型鱗狀上皮(ASCUS)及意義不明的不典型腺上皮(AGCUS) 478例,低度鱗狀上皮內病變(LISL) 175例,高度鱗狀上皮內病變(HSIL) 127例,鱗狀細胞癌(SCC)及腺癌(ACC)5例,高危型HPV感染率分彆為50.2％(240/478)、77.1％(135/175)、89.0％(113/127)、100.0％(5/5).高危型HPV感染暘性共493例,感染率為62.8％(493/785).26 ～ 30歲和51～55歲年齡組感染率較高,分彆為87.7 ％(71/81)、79.7％(51/64).＞55歲年齡組感染率低,為28.6％(14/54).高危型HPV感染暘性者中,前5種常見的高危型彆按暘性率遞減依次為HPV16(21.5％,169/785)、HPV52(12.2％,96/785)、HPV58(9.8％,77/785)、HPV33(9.7％,76/785)、HPV18(7.5％,59/785).單型高危型HPV感染率為45.0％(353/785),多型高危型HPV感染率為17.8％(140/785).其中2型感染98例,3型感染37例,4型感染2例,5型感染2例,6型感染1例.結論 與單純TCT篩查相比,高危型HPV檢測是子宮頸癌機會性篩查的有效手段.HPV16、52、58、33、18型在山東省聊城市子宮頸細胞學異常患者中感染率較高,多型感染增加患病風險,該區域高風險人群年齡多集中在26 ～ 30歲、51～ 55歲,需重視該年齡段人群的篩查及隨訪.
목적 료해산동성료성시자궁경세포학불동병리상태인군중고위형인유두류병독(HPV)감염상황급상견기인형,평개고위형HPV검측적응용개치.방법 대산동성료성시상주인구중18～70세이혼혹유성생활녀성우2013년1월지2014년1월진행자궁경액기세포학(TCT)사사,사사인수19 707인.사사결과양성837례,소회785례,채용고위형HPV류식세포술형광잡교xMAP기술진행분형검측,년령21 ～ 65세.대자료진행비교급묘술성분석.결과 785례녀성중,TCT진단위의의불명적불전형린상상피(ASCUS)급의의불명적불전형선상피(AGCUS) 478례,저도린상상피내병변(LISL) 175례,고도린상상피내병변(HSIL) 127례,린상세포암(SCC)급선암(ACC)5례,고위형HPV감염솔분별위50.2％(240/478)、77.1％(135/175)、89.0％(113/127)、100.0％(5/5).고위형HPV감염양성공493례,감염솔위62.8％(493/785).26 ～ 30세화51～55세년령조감염솔교고,분별위87.7 ％(71/81)、79.7％(51/64).＞55세년령조감염솔저,위28.6％(14/54).고위형HPV감염양성자중,전5충상견적고위형별안양성솔체감의차위HPV16(21.5％,169/785)、HPV52(12.2％,96/785)、HPV58(9.8％,77/785)、HPV33(9.7％,76/785)、HPV18(7.5％,59/785).단형고위형HPV감염솔위45.0％(353/785),다형고위형HPV감염솔위17.8％(140/785).기중2형감염98례,3형감염37례,4형감염2례,5형감염2례,6형감염1례.결론 여단순TCT사사상비,고위형HPV검측시자궁경암궤회성사사적유효수단.HPV16、52、58、33、18형재산동성료성시자궁경세포학이상환자중감염솔교고,다형감염증가환병풍험,해구역고풍험인군년령다집중재26 ～ 30세、51～ 55세,수중시해년령단인군적사사급수방.
Objectives To investigate the epidemiology of high-risk human papillomavirus (HPV) infection and the common genotypes in Liaocheng city, Shandong province, China, and to evaluate the application value of high risk HPV detection in cervical cytology with different pathological conditions.Methods A total of 19 707 permanent female residents in Liaocheng were recruited who were married or had sexual life, aged from 18 to 70 years old.They were screened for cervical cancer by thinprep liquid-based cytology test (TCT) from January 2013 to January 2014.The screen positive rate was 4.24 ％ (837/19 707), and 785 volunteers aged from 21 to 65 years old were recalled.The xMAP bead-based hybridization and flowcytometry analysis were used for genotyping.The data were analyzed by comparison and description.Results According to TCT, among 785 cases, there were 478 cases of atypical squamous epithelium of unknown significance (ASCUS) and atypical glandular epithelium of unknown significance (AGCUS), 175 cases of low-grade squamous intraepithelial lesion (LISL), 127 cases of high-grade squamous intraepithelial lesion (HSIL), 5 cases of squamous cell carcinoma (SCC) and adenocarcinoma (ACC).The positive rate of high-risk HPV was 62.8 ％ (493/785).The risk age of infection was 26-30 years old (87.7 ％, 71/81) and 51-55 years old (79.7 ％, 51/64), while a low risk one was found in patients older than 55 years old (28.6 ％, 14/54).The top five high-risk subtypes of HPV were HPV16 (21.5 ％, 169/785), HPV52 (12.2 ％, 96/785), HPV58 (9.8 ％, 77/785), HPV33 (9.7 ％, 76/785), HPV18 (7.5 ％, 59/785).Single infection accounted for 45.0 ％ (353/785), while multi-infection for 17.8 ％ (140/785).98 cases were infected by two subtypes, 37 cases by three subtypes, 2 cases by four subtypes, 2 cases by five subtypes and 1 case by six subtypes.Conclusions Compared with pure cervical TCT screening, high-risk HPV infection detection is an effective method for cervical cancer screening, which can improve the specificity of cervical cancer screening and reduce the omission diagnostic rate.In Liaocheng, HPV subtypes 16, 52, 58, 33, 18 and multi-infection are more prevalent.Women belonging to 26-30 or 51-55 years old are identified as high-risk population.Screening is important for this group to discover early cervical lesions.
