临床医学
臨床醫學
림상의학
Clinical Medicine
2015年
11期
31-32,33
,共3页
氯吡格雷%低分子肝素钠%老年不稳定型心绞痛%疗效
氯吡格雷%低分子肝素鈉%老年不穩定型心絞痛%療效
록필격뢰%저분자간소납%노년불은정형심교통%료효
Clopidogrel%Low molecular weight heparin%Elderly patients with unstable angina pectoris%Curative effect
目的：分析氯吡格雷联合低分子肝素钠治疗老年不稳定型心绞痛的疗效。方法选择深圳市宝安区石岩人民医院2012年5月至2014年5月收治的70例不稳定型心绞痛老年患者为研究对象，随机将其分为两组，对照组给予常规治疗，观察组在对照组基础上行氯吡格雷联合低分子肝素钠治疗，比较两组患者的临床疗效、不良反应、治疗前后心绞痛发作次数、总胆固醇（TC）水平及随访1个月心血管事件发生情况。结果观察组治疗总有效率、随访1个月时心绞痛再发及心肌梗死发生率分别为94.3%、2.8%、0，与对照组的74.3%、17.1%、11.4%比较差异有统计学意义（ P ＜0.05）。观察组治疗后心绞痛发作次数、TC 水平明显低于对照组（P ＜0.05）。两组不良反应发生率比较差异未见统计学意义（P ＞0.05）。结论氯吡格雷联合低分子肝素钠治疗老年不稳定型心绞痛疗效明确，能有效预防心肌梗死等不良心血管事件发生。
目的：分析氯吡格雷聯閤低分子肝素鈉治療老年不穩定型心絞痛的療效。方法選擇深圳市寶安區石巖人民醫院2012年5月至2014年5月收治的70例不穩定型心絞痛老年患者為研究對象，隨機將其分為兩組，對照組給予常規治療，觀察組在對照組基礎上行氯吡格雷聯閤低分子肝素鈉治療，比較兩組患者的臨床療效、不良反應、治療前後心絞痛髮作次數、總膽固醇（TC）水平及隨訪1箇月心血管事件髮生情況。結果觀察組治療總有效率、隨訪1箇月時心絞痛再髮及心肌梗死髮生率分彆為94.3%、2.8%、0，與對照組的74.3%、17.1%、11.4%比較差異有統計學意義（ P ＜0.05）。觀察組治療後心絞痛髮作次數、TC 水平明顯低于對照組（P ＜0.05）。兩組不良反應髮生率比較差異未見統計學意義（P ＞0.05）。結論氯吡格雷聯閤低分子肝素鈉治療老年不穩定型心絞痛療效明確，能有效預防心肌梗死等不良心血管事件髮生。
목적：분석록필격뢰연합저분자간소납치료노년불은정형심교통적료효。방법선택심수시보안구석암인민의원2012년5월지2014년5월수치적70례불은정형심교통노년환자위연구대상，수궤장기분위량조，대조조급여상규치료，관찰조재대조조기출상행록필격뢰연합저분자간소납치료，비교량조환자적림상료효、불량반응、치료전후심교통발작차수、총담고순（TC）수평급수방1개월심혈관사건발생정황。결과관찰조치료총유효솔、수방1개월시심교통재발급심기경사발생솔분별위94.3%、2.8%、0，여대조조적74.3%、17.1%、11.4%비교차이유통계학의의（ P ＜0.05）。관찰조치료후심교통발작차수、TC 수평명현저우대조조（P ＜0.05）。량조불량반응발생솔비교차이미견통계학의의（P ＞0.05）。결론록필격뢰연합저분자간소납치료노년불은정형심교통료효명학，능유효예방심기경사등불양심혈관사건발생。
Objective To analyze the curative effect of clopidogrel combined with low molecular heparin sodium in treatment of elderly patients with unstable angina pectoris. Methods Seventy elderly patients with of unstable angina pectaris from May 2012 to May 2014 were selected as the research object and were randomly divided into two groups,the control group was given routine treatment,and patients in the observation group was given clopidogrel combined with low molecular weight heparin sodium treatment on the basis of control group,the clinical curative effect,adverse reactions,angina attack frequency before and after the occurrence,level of TC and cardiovascular events followed up for 1 months of two groups were compared. Results The total efficiency of treatment,angina recurrence after 1 months and the incidence of myocardial infarction in observation group were 94. 3% ,2. 8% ,0,compared with control group of 74. 3% ,17. 1% ,11. 4% ,the differences were statistical significance(P <0. 05). The frequency of angina pectoris,TC levels in observation group after treatment were significantly lower than those of control group(P < 0. 05). The difference of incidence of adverse reactions in two groups had no significant difference(P >0. 05). Conclusion The effect of clopidogrel combined with low molecular heparin sodium in treatment of senile unstable angina pectoris is clear,can prevent myocardial infarction and other adverse cardiovascular events.
