临床医学
臨床醫學
림상의학
Clinical Medicine
2015年
11期
17-18
,共2页
子痫前期%胎盘%缺氧诱导因子-1
子癇前期%胎盤%缺氧誘導因子-1
자간전기%태반%결양유도인자-1
Preeclampsia%Placenta%Hypoxia inducible factor-1
目的：探讨低氧诱导因子-1（HIF-1）在胎盘中表达的升高及其所诱发的血管内皮损伤在子痫前期发病中的作用机制。方法免疫组化法检测子痫前期患者和正常晚孕妇女胎盘组织中 HIF-1和可溶性血管内皮生长因子受体-1（sFlt-1）的表达，ELISA 法检测母血中 sFlt-1的含量。结果子痫前期组胎盘中 HIF-1和 sFlt-1的表达以及母血 sFlt-1水平均较正常晚孕组升高。结论 HIF-1在胎盘组织中表达升高及其所诱发的血管内皮损伤在子痫前期发病中起重要作用。
目的：探討低氧誘導因子-1（HIF-1）在胎盤中錶達的升高及其所誘髮的血管內皮損傷在子癇前期髮病中的作用機製。方法免疫組化法檢測子癇前期患者和正常晚孕婦女胎盤組織中 HIF-1和可溶性血管內皮生長因子受體-1（sFlt-1）的錶達，ELISA 法檢測母血中 sFlt-1的含量。結果子癇前期組胎盤中 HIF-1和 sFlt-1的錶達以及母血 sFlt-1水平均較正常晚孕組升高。結論 HIF-1在胎盤組織中錶達升高及其所誘髮的血管內皮損傷在子癇前期髮病中起重要作用。
목적：탐토저양유도인자-1（HIF-1）재태반중표체적승고급기소유발적혈관내피손상재자간전기발병중적작용궤제。방법면역조화법검측자간전기환자화정상만잉부녀태반조직중 HIF-1화가용성혈관내피생장인자수체-1（sFlt-1）적표체，ELISA 법검측모혈중 sFlt-1적함량。결과자간전기조태반중 HIF-1화 sFlt-1적표체이급모혈 sFlt-1수평균교정상만잉조승고。결론 HIF-1재태반조직중표체승고급기소유발적혈관내피손상재자간전기발병중기중요작용。
Objective To investigate the role of HIF-1 increasing expression in placenta and the vessel endotheliocyte damage in pathophysiological changes of preeclampsia. Methods The HIF-1 and sFlt-1 expression in placenta were determined by immu-nohistochemistry,the maternal blood level of sFlt-1 was measured by the methord of ELISA. Results Compared with normal group,the HIF-1 and sFlt-1 expression in placenta,the blood level of sFlt-1 in preeclampsia group were all increased significlantly. Conclusion The HIF-1 increasing in placenta and the vessel endotheliocyte damage induced played important roles in preecampsia.
