CAJ | 학술논문

目的：探讨C-反应蛋白和胱抑素C联合检测诊断痛风患者早期肾功能损伤的临床效果。方法回顾性分析本院2014年6月至2015年6月收治的61例痛风患者的临床资料，按照是否合并早期肾功能损伤分为对照组（30例，未合并）和观察组（31例，合并）。检测两组的C-反应蛋白和胱抑素C，进行比较。并对观察组患者分别进行C-反应蛋白检测、胱抑素C检测和C-反应蛋白+胱抑素C检测，观察三种检测方法的阳性率，并进行比较。结果经检测和比较，观察组的C-反应蛋白和胱抑素C检测水平均显著高于对照组，经比较差异均有统计学意义，均P＜0.05，经不同的检测，观察组患者予以单纯C-反应蛋白检测和胱抑素C检测的阳性率均显著低于C-反应蛋白+胱抑素C检测，均P＜0.05；单纯C-反应蛋白检测的阳性率低于胱抑素C检测，但经比较差异无统计学意义，P＞0.05。结论较之单纯C-反应蛋白、胱抑素C检测，对痛风患者予以C-反应蛋白和胱抑素C联合检测可以达到较高的早期肾功能损伤阳性检出率。
목적：탐토C-반응단백화광억소C연합검측진단통풍환자조기신공능손상적림상효과。방법회고성분석본원2014년6월지2015년6월수치적61례통풍환자적림상자료，안조시부합병조기신공능손상분위대조조（30례，미합병）화관찰조（31례，합병）。검측량조적C-반응단백화광억소C，진행비교。병대관찰조환자분별진행C-반응단백검측、광억소C검측화C-반응단백+광억소C검측，관찰삼충검측방법적양성솔，병진행비교。결과경검측화비교，관찰조적C-반응단백화광억소C검측수평균현저고우대조조，경비교차이균유통계학의의，균P＜0.05，경불동적검측，관찰조환자여이단순C-반응단백검측화광억소C검측적양성솔균현저저우C-반응단백+광억소C검측，균P＜0.05；단순C-반응단백검측적양성솔저우광억소C검측，단경비교차이무통계학의의，P＞0.05。결론교지단순C-반응단백、광억소C검측，대통풍환자여이C-반응단백화광억소C연합검측가이체도교고적조기신공능손상양성검출솔。
Objective To explore the effect of C- reactive protein and cystatin C combined detection in the diagnosis of the clinical effect of early renal damage in patients with gout.Method A retrospective analysis was performed on clinical data of 61 patients with gout in our hospital from June 2014 to June 2015, and were divided into control group (30 cases, not complicated) and observation group (31 cases, combined) according to whether or not the early renal damage. Detection of C- reactive protein and cystatin C in two groups were compared. And to the patients in the observation group were the detection of C-reactive protein and cystatin C detection and C-reactive protein and cystatin C detection to observe the positive rate of three kinds of detection methods, and compared.Results After testing and comparison, the observation group of C-reactive protein and cystatin C detection level was significantly higher than that in the control group, to compare the differences were statistically significant (allP<0.05). The detection of different observed group of patients to be pure C-reactive protein detection and cystatin C detection positive rate were significantly lower than the detection of C-reactive protein and cystatin C (allP<0.05); pure C-reactive protein detection experimental rate lower than the detection of cystatin C, but the difference no statistical significance (P>0.05).Conclusion Compared with the simple C - reactive protein, Cystatin C detection. For patients with gout be combined detection of C-reactive protein and cystatin C can reach higher early renal function injury positive rate.