中国急救医学
中國急救醫學
중국급구의학
Chinese Journal of Critical Care Medicine
2015年
11期
1017-1021
,共5页
刘彤梅%王政%车琳%朱贵家
劉彤梅%王政%車琳%硃貴傢
류동매%왕정%차림%주귀가
对比剂肾病(CIN)%中性粒细胞和淋巴细胞的比值(NLR)%冠状动脉血管成像(CCTA)
對比劑腎病(CIN)%中性粒細胞和淋巴細胞的比值(NLR)%冠狀動脈血管成像(CCTA)
대비제신병(CIN)%중성립세포화림파세포적비치(NLR)%관상동맥혈관성상(CCTA)
Contrast-induced nephropathy ( CIN)%Neutrophil-to-lymphocyte ratio ( NLR)%Coronary computed tomographic angiography ( CCTA)
目的 探讨冠状动脉血管成像(CCTA)对比剂肾病(CIN)和外周血中性粒细胞和淋巴细胞比值( NLR)的相关性. 方法 入选我院心内科行冠状动脉CTA检查的患者,检查前及检查后24 h和48 h均给予静脉采血,比较CIN组和非对比剂肾病( NCIN)组患者NLR等相关指标的变化. 结果 入选研究对象为382例,CIN为24例,NCIN为358例,CIN组NLR和超敏C-反应蛋白( hs-CRP)较NCIN组明显增高( P<0.001 );慢性肾病患者CIN发生率较非慢性肾病患者高(r=0.281,P=0.012);糖尿病患者CIN发生率较非糖尿病患者高(r=0.359,P<0.001).年龄、基础肾小球滤过率、NLR及左室射血分数( LVEF)是CIN的独立预测因素. 结论 CCTA检查患者NLR可能是并发CIN实用有效的预测因素.
目的 探討冠狀動脈血管成像(CCTA)對比劑腎病(CIN)和外週血中性粒細胞和淋巴細胞比值( NLR)的相關性. 方法 入選我院心內科行冠狀動脈CTA檢查的患者,檢查前及檢查後24 h和48 h均給予靜脈採血,比較CIN組和非對比劑腎病( NCIN)組患者NLR等相關指標的變化. 結果 入選研究對象為382例,CIN為24例,NCIN為358例,CIN組NLR和超敏C-反應蛋白( hs-CRP)較NCIN組明顯增高( P<0.001 );慢性腎病患者CIN髮生率較非慢性腎病患者高(r=0.281,P=0.012);糖尿病患者CIN髮生率較非糖尿病患者高(r=0.359,P<0.001).年齡、基礎腎小毬濾過率、NLR及左室射血分數( LVEF)是CIN的獨立預測因素. 結論 CCTA檢查患者NLR可能是併髮CIN實用有效的預測因素.
목적 탐토관상동맥혈관성상(CCTA)대비제신병(CIN)화외주혈중성립세포화림파세포비치( NLR)적상관성. 방법 입선아원심내과행관상동맥CTA검사적환자,검사전급검사후24 h화48 h균급여정맥채혈,비교CIN조화비대비제신병( NCIN)조환자NLR등상관지표적변화. 결과 입선연구대상위382례,CIN위24례,NCIN위358례,CIN조NLR화초민C-반응단백( hs-CRP)교NCIN조명현증고( P<0.001 );만성신병환자CIN발생솔교비만성신병환자고(r=0.281,P=0.012);당뇨병환자CIN발생솔교비당뇨병환자고(r=0.359,P<0.001).년령、기출신소구려과솔、NLR급좌실사혈분수( LVEF)시CIN적독립예측인소. 결론 CCTA검사환자NLR가능시병발CIN실용유효적예측인소.
Objective We investigated the relationship between baseline neutrophil -to -lymphocyte ratio ( NLR ) and contrast -induced nephropathy ( CIN ) with computed tomographic angiography ( CCTA ) . Methods The study selected patients undergoing CCTA in Department of Cardiology in our hospital , giving venous blood pre -examination , 24 hour and 48 hour respectively , to see the changs related indicators , compare , NLR in CIN patients with non-CIN patients .Results In this study, a total of 382 patients were enrolled .A total of 24 patients developed CIN .Both NLR ( P<0.001) and C-reactive protein (P<0.001) levels were significantly higher in the CIN group when compared with the non-CIN group.There was a stronger correlation in patients with a known history of CKD (r=0.281, P=0.012) than in patients with no history of chronic kidney disease (CKD), and in patients with a history of diabetes mellitus (DM) than in patients with no history of DM (r=0.359, P<0.001).Multivariate logistic regression analysis revealed that advanced age , DM, baseline glomerular fitration rate( GFR) , NLR, and left ventricular ejection fractions ( LVEF) were independent predictors of CIN.Conclusion The NLR may be used as a simple and reliable indicator of CIN in patients who underwent CCTA .
