中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
Evaluation and Analysis of Drug-Use in Hospitals of China
2015年
11期
1444-1446
,共3页
左甲状腺素钠%钙剂%甲状腺功能减退症%联合用药
左甲狀腺素鈉%鈣劑%甲狀腺功能減退癥%聯閤用藥
좌갑상선소납%개제%갑상선공능감퇴증%연합용약
Levothyroxine sodium%Calcium%Hypothyroidism%Drug combination
目的：探讨左甲状腺素钠联合钙剂在不同服用时间对老年甲状腺功能减退症患者甲状腺激素的影响。方法：选取2011年4月—2014年3月间收治的150例老年甲状腺功能减退症患者为研究对象，按随机数字表法分为对照1组、对照2组和观察组，对照1组50例患者早晨空腹同时服用左甲状腺素钠与钙剂；对照2组50例患者早晨空腹服用左甲状腺素钠，睡前服用钙剂；观察组50例患者晚餐后4 h以上、睡前服用左甲状腺素钠，2餐间服用钙剂；观察各组患者的促甲状腺激素（ TSH）水平和临床疗效。结果：对照1组患者TSH较前有所上升，症状未改善；对照2组和观察组患者的TSH均较治疗前有所改善，且观察组改善程度较对照2组更明显，差异有统计学意义（ P＜0.05）。3组患者均未见明显不良反应。结论：老年甲状腺功能减退症患者晚餐后4h以上、睡前服用左甲状腺素钠，并与其他食物、药物隔开服用，临床效果更佳。
目的：探討左甲狀腺素鈉聯閤鈣劑在不同服用時間對老年甲狀腺功能減退癥患者甲狀腺激素的影響。方法：選取2011年4月—2014年3月間收治的150例老年甲狀腺功能減退癥患者為研究對象，按隨機數字錶法分為對照1組、對照2組和觀察組，對照1組50例患者早晨空腹同時服用左甲狀腺素鈉與鈣劑；對照2組50例患者早晨空腹服用左甲狀腺素鈉，睡前服用鈣劑；觀察組50例患者晚餐後4 h以上、睡前服用左甲狀腺素鈉，2餐間服用鈣劑；觀察各組患者的促甲狀腺激素（ TSH）水平和臨床療效。結果：對照1組患者TSH較前有所上升，癥狀未改善；對照2組和觀察組患者的TSH均較治療前有所改善，且觀察組改善程度較對照2組更明顯，差異有統計學意義（ P＜0.05）。3組患者均未見明顯不良反應。結論：老年甲狀腺功能減退癥患者晚餐後4h以上、睡前服用左甲狀腺素鈉，併與其他食物、藥物隔開服用，臨床效果更佳。
목적：탐토좌갑상선소납연합개제재불동복용시간대노년갑상선공능감퇴증환자갑상선격소적영향。방법：선취2011년4월—2014년3월간수치적150례노년갑상선공능감퇴증환자위연구대상，안수궤수자표법분위대조1조、대조2조화관찰조，대조1조50례환자조신공복동시복용좌갑상선소납여개제；대조2조50례환자조신공복복용좌갑상선소납，수전복용개제；관찰조50례환자만찬후4 h이상、수전복용좌갑상선소납，2찬간복용개제；관찰각조환자적촉갑상선격소（ TSH）수평화림상료효。결과：대조1조환자TSH교전유소상승，증상미개선；대조2조화관찰조환자적TSH균교치료전유소개선，차관찰조개선정도교대조2조경명현，차이유통계학의의（ P＜0.05）。3조환자균미견명현불량반응。결론：노년갑상선공능감퇴증환자만찬후4h이상、수전복용좌갑상선소납，병여기타식물、약물격개복용，림상효과경가。
OBJECTIVE:To probe into the effects of taking levothyroxine sodium and calcium at different time on the thyroid hormone of elderly patients with hypothyroidismin .METHODS:150 elderly hypothyroidism patients admitted into the hospital from Apr.2011 to Mar.2014 were selected as the research objects , who were divided into the control group one , control group two and the observation group .50 cases in the control group one were given levothyroxine sodium and calcium on an empty stomach.50 cases in the control two received levothyroxine sodium on an empty stomach , and calcium was given in bedtime .50 cases in observation group were given levothyroxine sodium at bedtime , after dinner of four hours , and took calcium between meals .The levels of thyroid stimulating hormone ( TSH ) and clinical efficacy of three group of patients were observed .RESULTS:TSH in control group one had increased 10 times,and the symptoms did not improve . Compared with before treatment , TSH in control group two and observation group were improved after treatment , and the observation group had been improved more significant than the control group two , with statistical difference ( P<0.05). There were no obvious adverse reactions in three groups .CONCLUSIONS:The elderly patients with hypothyroidism should take levothyroxine sodium in bedtime , after dinner of four hours , and other foods and medications should be separated from the drugs, by which the drugs could achieve a better clinical efficacy .
