针灸临床杂志
針灸臨床雜誌
침구림상잡지
Journal of Clinical Acupuncture and Moxibustion
2015年
11期
14-16
,共3页
孙晓伟%杨萌萌%栾仲秋%刘芷妤%李洪涛%滕伟%孟欣%盖利利
孫曉偉%楊萌萌%欒仲鞦%劉芷妤%李洪濤%滕偉%孟訢%蓋利利
손효위%양맹맹%란중추%류지여%리홍도%등위%맹흔%개리리
头针%体针%急性脑梗死%颈动脉粥样硬化%基质金属蛋白酶2
頭針%體針%急性腦梗死%頸動脈粥樣硬化%基質金屬蛋白酶2
두침%체침%급성뇌경사%경동맥죽양경화%기질금속단백매2
Scalp acupuncture%Body acupuncture%Acute cerebral infarction%Carotid atherosclerosis%MMP - 2
目的:探讨头体针结合疗法治疗急性颈动脉粥样硬化性脑梗死的疗效,以及对患者血清炎性标记物MMP-2和预后的影响.方法:选取102例急性颈动脉粥样硬化性脑梗死患者,随机分为两组,每组51例,分别采用针刺加常规药物治疗(治疗组)和常规药物治疗(对照组),观察比较两组的疗效,测定治疗前后血清MMP-2水平的变化及预后.结果:治疗组基本痊愈28例,显著进步16例,进步6例,无效1例,总有效率为98.1%;对照组基本痊愈18例,显著进步17例,进步10例,无效6例,总有效率为88.2%.两组疗效比较差异具有统计学意义(P<0.05),治疗组优于对照组.治疗组患者治疗后2周和4周,血清MMP-2水平较疗前有明显降低( P<0.05 ),对照组患者治疗后4周血清MMP-2水平较疗前明显降低(P<0.05).两组患者MMP-2水平在疗后2周和4周比较均有显著差异(P<0.05),且治疗组较对照组降低更明显.结论:头体针结合疗法治疗急性颈动脉粥样硬化性脑梗死疗效确切,能显著降低患者的MMP-2水平,减轻炎症反应,稳定动脉粥样硬化斑块,继而降低脑梗死的发生,减轻再灌注级联损伤,可在临床推广.
目的:探討頭體針結閤療法治療急性頸動脈粥樣硬化性腦梗死的療效,以及對患者血清炎性標記物MMP-2和預後的影響.方法:選取102例急性頸動脈粥樣硬化性腦梗死患者,隨機分為兩組,每組51例,分彆採用針刺加常規藥物治療(治療組)和常規藥物治療(對照組),觀察比較兩組的療效,測定治療前後血清MMP-2水平的變化及預後.結果:治療組基本痊愈28例,顯著進步16例,進步6例,無效1例,總有效率為98.1%;對照組基本痊愈18例,顯著進步17例,進步10例,無效6例,總有效率為88.2%.兩組療效比較差異具有統計學意義(P<0.05),治療組優于對照組.治療組患者治療後2週和4週,血清MMP-2水平較療前有明顯降低( P<0.05 ),對照組患者治療後4週血清MMP-2水平較療前明顯降低(P<0.05).兩組患者MMP-2水平在療後2週和4週比較均有顯著差異(P<0.05),且治療組較對照組降低更明顯.結論:頭體針結閤療法治療急性頸動脈粥樣硬化性腦梗死療效確切,能顯著降低患者的MMP-2水平,減輕炎癥反應,穩定動脈粥樣硬化斑塊,繼而降低腦梗死的髮生,減輕再灌註級聯損傷,可在臨床推廣.
목적:탐토두체침결합요법치료급성경동맥죽양경화성뇌경사적료효,이급대환자혈청염성표기물MMP-2화예후적영향.방법:선취102례급성경동맥죽양경화성뇌경사환자,수궤분위량조,매조51례,분별채용침자가상규약물치료(치료조)화상규약물치료(대조조),관찰비교량조적료효,측정치료전후혈청MMP-2수평적변화급예후.결과:치료조기본전유28례,현저진보16례,진보6례,무효1례,총유효솔위98.1%;대조조기본전유18례,현저진보17례,진보10례,무효6례,총유효솔위88.2%.량조료효비교차이구유통계학의의(P<0.05),치료조우우대조조.치료조환자치료후2주화4주,혈청MMP-2수평교료전유명현강저( P<0.05 ),대조조환자치료후4주혈청MMP-2수평교료전명현강저(P<0.05).량조환자MMP-2수평재료후2주화4주비교균유현저차이(P<0.05),차치료조교대조조강저경명현.결론:두체침결합요법치료급성경동맥죽양경화성뇌경사료효학절,능현저강저환자적MMP-2수평,감경염증반응,은정동맥죽양경화반괴,계이강저뇌경사적발생,감경재관주급련손상,가재림상추엄.
Objective:To investigate the therapeutic effect of acupuncture on acute cerebral infarction with ca-rotid artery atherosclerosis,and the influence of serum MMP -2 and prognosis in the patients.Methods:Select 102 patients with acute carotid atherosclerotic cerebral infarction,and they were randomly divided into two groups,with 51 cases in each group,and two groups are respectively treated with acupuncture plus conventional medicine ( the acupuncture group ) and conventional drug treatment ( the control group ).Observe the efficacy of two groups and determine the changes of serum MMP -2 level and prognosis in the patients before and after treatment.Results:In the treatment group,28 cases were cured;16 cases were improved significantly;6 cases were improved;1 case was invalid,and the total effective rate was 98.1%;in the control group,18 cases were cured;17 cases were improved significantly;10 cases were improved;6 cases were invalid,and the total effec-tive rate was 88.2%.The difference of efficacy between two groups was statistically significant (P<0.05) and the treatment group was better than the control group.In the treatment group,the level of serum MMP-2 in the patients was significantly decreased after 2 weeks and 4 weeks of the treatment ( P<0.05 ) and in the control group the level of serum MMP -2 in the patients was significantly decreased after 4 weeks of the treatment ( P<0.05 ).The level of MMP-2 in the patients of two groups was significantly different between 2 and 4 weeks'treatment,and the treatment group was significantly lower than the control group.Conclusion : The efficacy of scalp and body acupuncture therapy in the treatment of acute carotid atherosclerotic cerebral infarction is exact,and this therapy can significantly reduce the level of serum MMP -2 in the patients,reduce inflammation,sta-bilize atherosclerotic plaque and reduce the occurrence of cerebral infarction,mitigate reperfusion injury and can be popularized in clinic.