CAJ | 학술논문

荚膜多糖是细菌的主要保护性抗原和毒力因子，具有较好的免疫原性，是最适宜做疫苗的细菌靶抗原之一。荚膜多糖疫苗与传统疫苗相比，由于其成分单一，不存在易引起免疫副反应的物质，使得该疫苗更安全、有效，已成为世界上应用最多的疫苗之一。近年来在人医和兽医方面均对荚膜多糖疫苗进行了广泛深入的研究，并取得了一定的进展。论文对荚膜多糖的生物学作用、作用机制、提取纯化工艺及影响因素，荚膜多糖疫苗的研制及应用等方面进行了综述，同时对荚膜多糖疫苗的发展前景以及存在的问题进行了总结，以期为荚膜多糖的进一步研究提供借鉴。
협막다당시세균적주요보호성항원화독력인자，구유교호적면역원성，시최괄의주역묘적세균파항원지일。협막다당역묘여전통역묘상비，유우기성분단일，불존재역인기면역부반응적물질，사득해역묘경안전、유효，이성위세계상응용최다적역묘지일。근년래재인의화수의방면균대협막다당역묘진행료엄범심입적연구，병취득료일정적진전。논문대협막다당적생물학작용、작용궤제、제취순화공예급영향인소，협막다당역묘적연제급응용등방면진행료종술，동시대협막다당역묘적발전전경이급존재적문제진행료총결，이기위협막다당적진일보연구제공차감。
Capsular polysaccharides(CP)are protective antigens and virulence factors of bacteria,which have good immunogenicity and are ideal candidates as vaccines.Compared with traditional vaccines,capsu-lar polysaccharide vaccines (CPV)are safer and more effective with single component.As a result,they have become one of the world's most widely used vaccines.People have carried out a lot of experiments and made some progress on the CPV of both human and animals in recent years.This review focused on the bi-osynthesis and biological function of CP,the mechanism on CPV,and the research progress of CPV at home and abroad.The advantages and disadvantages of CPV were also analyzed.This is useful for the fur-ther study of CPV.