CAJ | 학술논문

目的：：中西医结合与单纯西药治疗尿酸性肾病的临床疗效及安全性的观察。方法：将68例尿酸性肾病患者采用随机方法分为两组,治疗组(中西医结合组)和对照组(西药组),都给予基本饮食治疗及别嘌呤醇治疗,治疗组在对照组基础上加用中药威草胶囊治疗,15d 为1个疗程,共治疗4个疗程,观察患者临床症状,并于治疗前后检测肾功能、血脂等情况。结果：治疗后总有效率治疗组91.67%优于对照组68.75%(P<0.05)；治疗组治疗后血尿酸(SUA)、尿素氮(BUN)、β2微球蛋白(β2-MG)及24h尿蛋白尿定量、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、载脂蛋白 B(ApoB)均较治疗前降低(P<0.05)；对照组SUA、TC较治疗前降低(P<0.05)；治疗组 BUN、β2-MG、24h 尿蛋白尿定量、TC、TG、LDL-C降低优于对照组(P<0.05)；治疗组高密度脂蛋白(HDL-C)、载脂蛋白 A1(ApoA1)较治疗前升高(P<0.05)；治疗组 HDL-C 升高优于对照组(P<0.05),且中西药联合应用能有效的减轻临床症状,治疗过程中未发生严重不良反应。结论：威草胶囊联合西药治疗慢性尿酸性肾病有很好的临床疗效,且应用安全。
목적：：중서의결합여단순서약치료뇨산성신병적림상료효급안전성적관찰。방법：장68례뇨산성신병환자채용수궤방법분위량조,치료조(중서의결합조)화대조조(서약조),도급여기본음식치료급별표령순치료,치료조재대조조기출상가용중약위초효낭치료,15d 위1개료정,공치료4개료정,관찰환자림상증상,병우치료전후검측신공능、혈지등정황。결과：치료후총유효솔치료조91.67%우우대조조68.75%(P<0.05)；치료조치료후혈뇨산(SUA)、뇨소담(BUN)、β2미구단백(β2-MG)급24h뇨단백뇨정량、총담고순(TC)、감유삼지(TG)、저밀도지단백(LDL-C)、재지단백 B(ApoB)균교치료전강저(P<0.05)；대조조SUA、TC교치료전강저(P<0.05)；치료조 BUN、β2-MG、24h 뇨단백뇨정량、TC、TG、LDL-C강저우우대조조(P<0.05)；치료조고밀도지단백(HDL-C)、재지단백 A1(ApoA1)교치료전승고(P<0.05)；치료조 HDL-C 승고우우대조조(P<0.05),차중서약연합응용능유효적감경림상증상,치료과정중미발생엄중불량반응。결론：위초효낭연합서약치료만성뇨산성신병유흔호적림상료효,차응용안전。
Obj ective:Observe the clinical efficacy of Weicao capsule combined with western medicine and sin-gle western medicine in treating chornic uric acid nephropathy.Methods:68 patients with uric acid kidney disease were di-vided into two groups randomly,the treatment group (integrative medicine group)and the control group (western medi-cine group),both of patients were given basic dietary treatment and allopurinol,the treatment group were given Weicao capsule on the base of the control group,1 5 days for a course,a total of four courses of the treatment,then observe the clinical symptoms,and detect kidney function,blood lipids,etc before and after treatment.Results :After the treatment, the total efficiency of the treatment group 91.67% was better than the control group 68.75% (P<0.05);serum uric acid (SUA),blood urea nitrogen (BUN),β2-microglobulin (β2-MG)and 24h quantitative urinary proteinuria,total cholester-ol (TC),triglyceride (TG),low density lipoprotein (LDL-C),apolipoprotein B (ApoB)were lower than that before the treatment in the treatment group (P<0.05);SUA and TC were lower than that before the treatment in the control group (P<0.05);BUN,β2-MG,24h urinary proteinuria quantification,TC,TG,LDL-C in the treatment group were lower than that of the control group (P<0.05);after the treatment,high-density lipoprotein (HDL-C)and apolipoprotein A1 (ApoA1)were increased in the treatment group (P<0.05);and HDL-C in treatment group were higher than that of the control group (P<0.05),and the combination of Chinese and western medicine can effectively reduce the clinical symp-toms ,there were no serious adverse events occur during the treatment.Conclusion:Weicao capsules combined with west-ern medicine have a good clinical effect in chronic uric acid nephropathy,and its application is safe.