CAJ | 학술논문

目的：探讨术前放射治疗对中晚期胃癌患者临床疗效的影响。方法选取2008年10月至2013年10月福建医科大学附属南平市第一医院收治的167例中晚期胃癌患者，根据有无进行术前放射治疗将患者分为两组：非放射治疗组（79例），患者均未进行术前放射治疗仅进行单纯手术切除；放射治疗组（88例），患者均先进行放射治疗再进行手术切除。分析两组患者的治疗有效率、根治手术切除率、手术病死率、并发症发生率及5年生存率。结果放射治疗组的治疗有效率（67.4％）、根治手术切除率（92.3％）、5年生存率（35.7％）均高于非放射治疗组的50.3％、82.0％、20.8％，差异有统计学意义（χ2＝5.04，4.02，4.52，均 P ＜0.05）；放射治疗组手术病死率（2.5％）和非放射治疗组的1.4％比较，差异无统计学意义（P＞0.05）；放射治疗组并发症发生率（7.8％）和非放射治疗组的7.4％比较，差异无统计学意义（ P ＞0.05）。结论中晚期胃癌患者手术前进行放谢治疗可提高根治手术切除率、治疗有效率和5年生存率，但对并发症发生率和手术病死率影响不大。
목적：탐토술전방사치료대중만기위암환자림상료효적영향。방법선취2008년10월지2013년10월복건의과대학부속남평시제일의원수치적167례중만기위암환자，근거유무진행술전방사치료장환자분위량조：비방사치료조（79례），환자균미진행술전방사치료부진행단순수술절제；방사치료조（88례），환자균선진행방사치료재진행수술절제。분석량조환자적치료유효솔、근치수술절제솔、수술병사솔、병발증발생솔급5년생존솔。결과방사치료조적치료유효솔（67.4％）、근치수술절제솔（92.3％）、5년생존솔（35.7％）균고우비방사치료조적50.3％、82.0％、20.8％，차이유통계학의의（χ2＝5.04，4.02，4.52，균 P ＜0.05）；방사치료조수술병사솔（2.5％）화비방사치료조적1.4％비교，차이무통계학의의（P＞0.05）；방사치료조병발증발생솔（7.8％）화비방사치료조적7.4％비교，차이무통계학의의（ P ＞0.05）。결론중만기위암환자수술전진행방사치료가제고근치수술절제솔、치료유효솔화5년생존솔，단대병발증발생솔화수술병사솔영향불대。
Objective To investigate the clinical efficacy of radiotherapy before surgery on patients with advanced gastric cancer.Methods Total of 167 cases with advanced gastric cancer in Fujian Medical Uni-versity Affiliated Nanping City First Hospital from Oct.2008 to Oct.2013 were included in the study,accord-ing to the presence or absence of preoperative radiotherapy the patients were divided into two groups:non-radiotherapy group ( 79 cases ) , the patients received no radiotherapy before surgical excision; radiotherapy group(88 cases) ,the patients were treated with radiotherapy before surgery.The therapeutic efficacy,radical resection rate,operative mortality,complication incidence,and 5-year survival rate were analyzed.Results The therapeutic efficacy(67.4%),radical resection rate (92.3%),5-year survival rate (35.7%) of the radiotherapy group were higher than 50.3%,82.0%,20.8%,of the non-radiotherapy group,the differences were statistically significant (χ2 =5.04,4.02,4.52,all P<0.05);the mortality in the radiotherapy group (2.5%) and the non-radiotherapy group(1.4%) had no statistically significant difference(P>0.05); the incidence of complications of the radiotherapy group (7.8%) and and the non-radiotherapy group(7.4%) had no statistically significant difference ( P >0.05 ) .Conclusion Preoperative radiotherapy can increase the radical resection rate,therapeutic efficacy and 5-year survival for patients with advanced gastric cancer, with only little effect on the complication incidence and the mortality .