CAJ | 학술논문

目的：探讨高血压患者执行Go－Nogo任务时冲突监控机制的特点及与MMSE评分的相关性。方法选取高血压患者、正常对照各15例为研究对象，采用MMSE量表及视觉事件相关电位Go－Nogo实验范式，记录行为学数据和32导脑电数据。结果两组被试的Go刺激平均反应时、命中率无差异性，P＞0．05。Nogo－N2波幅[F（1，27）＝3．081，P＝0．038]、潜伏期[F（1，27）＝2．582，P＝0．047]组间比较，P＜0．05。 Go－N2波幅、潜伏期组间比较，P＞0．05。高血压组MMSE评分显著低于正常对照（ P＜0．05），高血压组Nogo-N2潜伏期与MMSE分数呈负相关，相关系数为－0．293，P＝0．036＜0．05。结论高血压患者在200～300ms时间窗内冲突监控机制异常，Nogo-N2潜伏期与高血压患者MMSE评分相关，Nogo-N2可能对认知功能的诊断有潜在的价值，为高血压患者认知功能的进一步研究提供神经电生理依据。
목적：탐토고혈압환자집행Go－Nogo임무시충돌감공궤제적특점급여MMSE평분적상관성。방법선취고혈압환자、정상대조각15례위연구대상，채용MMSE량표급시각사건상관전위Go－Nogo실험범식，기록행위학수거화32도뇌전수거。결과량조피시적Go자격평균반응시、명중솔무차이성，P＞0．05。Nogo－N2파폭[F（1，27）＝3．081，P＝0．038]、잠복기[F（1，27）＝2．582，P＝0．047]조간비교，P＜0．05。 Go－N2파폭、잠복기조간비교，P＞0．05。고혈압조MMSE평분현저저우정상대조（ P＜0．05），고혈압조Nogo-N2잠복기여MMSE분수정부상관，상관계수위－0．293，P＝0．036＜0．05。결론고혈압환자재200～300ms시간창내충돌감공궤제이상，Nogo-N2잠복기여고혈압환자MMSE평분상관，Nogo-N2가능대인지공능적진단유잠재적개치，위고혈압환자인지공능적진일보연구제공신경전생리의거。
Objective To investigate the conflict monitoring mechanisms in patients with hypertension when performing Go /Nogo task and discussed the relationship between Go-N2, Nogo-N2 and the MMSE.Methods Selected 15 cases of hypertension patients and 15 cases of normal controls,using MMSE scale and visual event-related potentials Go-Nogo experimental paradigm, Behavior data and 32 channel EEG data were recorded.Results Behavior data of two groups were not significant difference(P>0.05), The results showed that ERP system: The amplitude (F(1,27)=3.081,P=0.038) and latency of Nogo-N2(F(1,27)=2.582,P=0.047) were significant difference between groups, P<0.05.The amplitude and latency of Go-N2 were not significant difference(P>0.05). Hypertension group MMSE score was significantly lower than the control group( P<0.05) .The latency of Nogo-N2 were negatively correlated to the MMSE scores,r =-0.293,P=0.036<0.05.Conclusion Hypertensive patients in the 200-300ms time window abnormal conflict monitoring mechanisms, Nogo-N2 latencies associated with MMSE score of hypertension patients, Nogo-N2 may have potential diagnostic value for cognitive function in patients with hypertension,provide neurophysiological basis for further study of cognitive function in patients with hypertension.