CAJ | 학술논문

目的：通过阴道微生态评价指标，了解外阴阴道假丝酵母菌病（ VVC）患者与健康人群的阴道微生态差异。方法：随机选取四川大学华西第二医院妇科门诊诊断为VVC患者199例，健康育龄妇女412例。经调查病史、年龄后，取阴道分泌物进行阴道微生态检查，包括菌群密集度、菌群多样性、乳酸杆菌、乳酸杆菌分级、唾液酸酶、Nugent评分、白细胞、清洁度、线索细胞、pH值等，进行分析比较。结果：VVC组与健康对照组比较，除菌群多样性和pH值没有显著性差异（P＞0.05）外，其余指标均有显著性差异（P＜0.05）。 VVC患者平均年龄显著低于健康妇女，菌群密集度、乳酸杆菌、乳酸杆菌分级、唾液酸酶、Nugent评分、白细胞、清洁度和线索细胞明显高于健康对照组。结论：VVC好发于低年龄育龄妇女；通过监测阴道微生态指标的改变，临床医生可根据VVC患者的具体微生态状况而针对性用药。
목적：통과음도미생태평개지표，료해외음음도가사효모균병（ VVC）환자여건강인군적음도미생태차이。방법：수궤선취사천대학화서제이의원부과문진진단위VVC환자199례，건강육령부녀412례。경조사병사、년령후，취음도분비물진행음도미생태검사，포괄균군밀집도、균군다양성、유산간균、유산간균분급、타액산매、Nugent평분、백세포、청길도、선색세포、pH치등，진행분석비교。결과：VVC조여건강대조조비교，제균군다양성화pH치몰유현저성차이（P＞0.05）외，기여지표균유현저성차이（P＜0.05）。 VVC환자평균년령현저저우건강부녀，균군밀집도、유산간균、유산간균분급、타액산매、Nugent평분、백세포、청길도화선색세포명현고우건강대조조。결론：VVC호발우저년령육령부녀；통과감측음도미생태지표적개변，림상의생가근거VVC환자적구체미생태상황이침대성용약。
Objective:To investigate the vaginal micro ecological differences between patients with VVC (case group) and healthy women of reproductive age ( control group ) through the evaluation of vaginal micro ecological indicators .Methods:199 patients who were diagnosed as VVC in gynecological outpatient department of West China Second University Hospital , Sichuan University and 412 women of control group were enrolled in our study randomly .Their mrdical history and ages were investigated , and the vaginal micro ecosystem of vaginal discharge were evaluated , which were bacteria density , flora diversity , Lactobacillus , Lactobacillus classification,sialidase,Nugent scores,white blood cells,vaginal depuratory degree ,clue cells,pH value and so on. The differences between the two study groups were calculated with statistical methods .Results:There were significant differences between the case group and the control group inmicro ecological indicators ( P<0.05) except flora diversity and pH value ( P>0.05).The average age of patients with VVC was lower than that of healthy women .The bacteria density, Lactobacillus, Lactobacillus classification,sialidase,Nugent score, white blood cells,vaginal depuratory degree and clue cells of patients with VVC were significantly higher than that of healthy women .Conclusion:VVC often occurs in women of low reproductive age .By monitoring the changes of vaginal micro -ecosystem,clinicians can use targeted drugs in treatment of patients with VVC according to the specific micro ecological status .