医学综述
醫學綜述
의학종술
Medical Recapitulate
2015年
21期
3975-3976
,共2页
血糖波动%重症患者%预后
血糖波動%重癥患者%預後
혈당파동%중증환자%예후
Blood glucose variability%Critically ill patients%Prognosis
目的:探讨血糖波动对重症患者预后的影响。方法回顾性分析2013年6月至2014年2月苏州市中西医结合医院收治的79例入住重症监护病房( ICU)当日急性生理学与慢性健康状况评分Ⅱ( APACHE-Ⅱ)评分≥15分、住ICU时间≥3 d的危重症患者的临床资料,监测入住 ICU 72 h内血糖值,记录初始血糖( GluAdm)、72 h内平均血糖( GluAve)、血糖标准差( GluSD)、血糖变异率( GluCV)。根据入住ICU后28 d 预后情况分为存活组( n =50)与死亡组( n =29)。比较两组间APACHE-Ⅱ评分、GluAdm、GluAve、GluSD、GluCV 的差异。结果死亡组患者 APACHE-Ⅱ评分、GluSD和GluCV均显著高于存活组[(28±10)分比(20±8)分,(2.8±1.7) mmol/L 比(1.9±0.7) mmol/L,(0.34±0.13)%比(0.23±0.07)%,P<0.01],GluAdm、GluAve在存活组和死亡组间差异无统计学意义( P >0.05)。 Pearson 相关分析显示, GluSD 与 APACHE-Ⅱ评分呈正相关( r =0.583,P<0.01)。结论危重患者血糖波动与28 d 病死率密切相关,降低血糖波动有利于改善患者预后。
目的:探討血糖波動對重癥患者預後的影響。方法迴顧性分析2013年6月至2014年2月囌州市中西醫結閤醫院收治的79例入住重癥鑑護病房( ICU)噹日急性生理學與慢性健康狀況評分Ⅱ( APACHE-Ⅱ)評分≥15分、住ICU時間≥3 d的危重癥患者的臨床資料,鑑測入住 ICU 72 h內血糖值,記錄初始血糖( GluAdm)、72 h內平均血糖( GluAve)、血糖標準差( GluSD)、血糖變異率( GluCV)。根據入住ICU後28 d 預後情況分為存活組( n =50)與死亡組( n =29)。比較兩組間APACHE-Ⅱ評分、GluAdm、GluAve、GluSD、GluCV 的差異。結果死亡組患者 APACHE-Ⅱ評分、GluSD和GluCV均顯著高于存活組[(28±10)分比(20±8)分,(2.8±1.7) mmol/L 比(1.9±0.7) mmol/L,(0.34±0.13)%比(0.23±0.07)%,P<0.01],GluAdm、GluAve在存活組和死亡組間差異無統計學意義( P >0.05)。 Pearson 相關分析顯示, GluSD 與 APACHE-Ⅱ評分呈正相關( r =0.583,P<0.01)。結論危重患者血糖波動與28 d 病死率密切相關,降低血糖波動有利于改善患者預後。
목적:탐토혈당파동대중증환자예후적영향。방법회고성분석2013년6월지2014년2월소주시중서의결합의원수치적79례입주중증감호병방( ICU)당일급성생이학여만성건강상황평분Ⅱ( APACHE-Ⅱ)평분≥15분、주ICU시간≥3 d적위중증환자적림상자료,감측입주 ICU 72 h내혈당치,기록초시혈당( GluAdm)、72 h내평균혈당( GluAve)、혈당표준차( GluSD)、혈당변이솔( GluCV)。근거입주ICU후28 d 예후정황분위존활조( n =50)여사망조( n =29)。비교량조간APACHE-Ⅱ평분、GluAdm、GluAve、GluSD、GluCV 적차이。결과사망조환자 APACHE-Ⅱ평분、GluSD화GluCV균현저고우존활조[(28±10)분비(20±8)분,(2.8±1.7) mmol/L 비(1.9±0.7) mmol/L,(0.34±0.13)%비(0.23±0.07)%,P<0.01],GluAdm、GluAve재존활조화사망조간차이무통계학의의( P >0.05)。 Pearson 상관분석현시, GluSD 여 APACHE-Ⅱ평분정정상관( r =0.583,P<0.01)。결론위중환자혈당파동여28 d 병사솔밀절상관,강저혈당파동유리우개선환자예후。
Objective To explore the correlation between glucose variability and mortality in critical patients.Methods Seventy-nine patients,with acute physiology and chronic health evalu-ation scoring system (APACHE-Ⅱ) score on admission day ≥15,the duration of ICU stay ≥3 d,in ICU of Suzhou Integrated Traditional and Western Medicine Hospital from Jun.2013 to Feb.2014 were included in the study,according to the patient′s prognosis on the 28th day,they were divided into survivor group(n =50) and nonsurvivor group(n=29),and the blood glucose level in the first 72 h was monitors:the initial blood glucose(Glu-Adm),the mean value of 72h(GluAve),standard deviation of blood glucose(GluSD) and variation coeffi-cient of blood glucose ( GluCV) of the two groups were recorded.APACHE-Ⅱ score, GluAdm, GluAve, GluSD,GluCV of the two groups were compared.Results The levels of APACHE-Ⅱ score, GluSD and GluCV of nonsurvior group were higher than those of survivor group[APACHE-Ⅱ(28 ±10) vs (20 ±8), GluSD(2.8 ±1.7) mmol/L vs (1.9 ±0.7) mmol/L,GluCV(0.34 ±0.13)% vs (0.23 ±0.07)%,P<0.01],but there was no statistically significant difference in the levels of GluAdm and GluAve(P>0.05). Pearson correlation analysis showed that GluSD was positively correlated with APACHE-II score (r=0.583, P<0.01).Conclusion Variability of blood glucose has close relation to short-term mortality(28 days). Control of the fluctuation of blood glucose is helpful to improve the prognosis .