CAJ | 학술논문

微RNA－7（miR－7）是23个核苷酸长的非编码小分子RNA，其在多种肿瘤组织中的表达降低，与肿瘤生长、转移等密切相关。 miR－7作为一个肿瘤抑制因子，可抑制表皮生长因子受体、胰岛素样生长因子1受体等基因的表达，从而抑制肿瘤的发生、发展。此外，miR－7还能提高肿瘤对化疗的敏感性，并抑制肿瘤血管生成。 miR－7本身也受细胞内复杂机制的调控，其表达量变化及其对肿瘤的调控可为肿瘤的诊治提供新思路，具有良好的潜在临床应用前景。
미RNA－7（miR－7）시23개핵감산장적비편마소분자RNA，기재다충종류조직중적표체강저，여종류생장、전이등밀절상관。 miR－7작위일개종류억제인자，가억제표피생장인자수체、이도소양생장인자1수체등기인적표체，종이억제종류적발생、발전。차외，miR－7환능제고종류대화료적민감성，병억제종류혈관생성。 miR－7본신야수세포내복잡궤제적조공，기표체량변화급기대종류적조공가위종류적진치제공신사로，구유량호적잠재림상응용전경。
MicroRNA-7(miR-7) is a 23-nucleartide small non-coding RNA whose expression is down-regulated in various cancers and has been linked to cancer growth as well as metastasis.Acting as a tumor suppressor,miR-7 can suppress tumor growth via inhibiting the expression of critical genes such as epidermal growth factor receptor,insulin-like growth factor-1 receptor.Meanwhile,miR-7 can also inhibit tumor angio-genesis and promote its sensitivity to chemotherapy.In addition,miR-7 itself is regulated by some complex intracellular mechanisms.Based on its changed expression and its role in regulating cancer development , miR-7 shows potential clinical applications in cancer diagnosis and therapy.