CAJ | 학술논문

2型糖尿病（T2DM）是由遗传因素和环境因素共同作用而形成的多基因遗传性疾病，是一种复杂的异质性的糖代谢性疾病，主要包括高血糖反应、胰岛功能受损和（或）胰岛素分泌障碍。T2DM可引起多器官或组织功能失调。目前T2DM的发病机制尚未完全明确，但近年来的研究进展已对 T2DM 的认识带来了一些全新的面貌，特别是环境因素与遗传因素在分子水平的认识已为T2DM的治疗开辟了一些鼓舞人心的新领域。
2형당뇨병（T2DM）시유유전인소화배경인소공동작용이형성적다기인유전성질병，시일충복잡적이질성적당대사성질병，주요포괄고혈당반응、이도공능수손화（혹）이도소분비장애。T2DM가인기다기관혹조직공능실조。목전T2DM적발병궤제상미완전명학，단근년래적연구진전이대 T2DM 적인식대래료일사전신적면모，특별시배경인소여유전인소재분자수평적인식이위T2DM적치료개벽료일사고무인심적신영역。
Type 2 diabetes mellitus(T2DM) is a polygenes heredity disease caused by both the genetic and environmental factors.T2DM is a complex heterogeneous disease of the glucose metabolic disorder, including the reaction of hyperglycemia and the impairment of pancreatic islets function and/or insulin secre-tion.T2DM is accompanied with the dysfunctions of multiple organs or tissues.Although the pathogenesis of T2DM remains unclear,the recent researches about it has presented some new views.These researches pio-neer some inspiring new areas for T2DM treatment,especially in the molecular mechanisms of environmental and genetic factors.