浙江中西医结合杂志
浙江中西醫結閤雜誌
절강중서의결합잡지
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
2015年
11期
1003-1006
,共4页
吴漳益%金心%蔡钟钦%缪旭云
吳漳益%金心%蔡鐘欽%繆旭雲
오장익%금심%채종흠%무욱운
脑损伤%芳香开窍药%脑血流速度%脑血流量%CT灌注成像
腦損傷%芳香開纖藥%腦血流速度%腦血流量%CT灌註成像
뇌손상%방향개규약%뇌혈류속도%뇌혈류량%CT관주성상
Brain injury%Aromatic resuscitation drug%Cerebral blood flow velocity%Cerebralbloodflow%CT per-fusion imaging
目的 研究芳香开窍药经鼻给药对脑损伤后意识障碍患者脑血流速度及脑血流量的影响,并观察其促苏醒作用.方法 60例脑损伤后意识障碍患者随机分为治疗组、对照组,各30例,两组均给予常规促醒治疗,治疗组在常规治疗的基础上加用芳香开窍药经鼻给药治疗.两组治疗前后均行经颅多普勒脑血管超声检测患者大脑中动脉(MCA)、基底动脉(BA)平均血流速度,对脑损伤区进行CT灌注成像扫描(CTPI).治疗前后行Glasgow昏迷评分(GCS)进行疗效评定.结果 治疗1个月后,治疗组大脑中动脉(MCA)及基底动脉(BA)平均血流速度均快于对照组[(93.65± 9.71)cm/s比(81.43±9.52)cm/s),P<0.05;(37.23±5.42)cm/s比(31.52±4.12)cm/s,P<0.05].治疗后治疗组CTPI参数rCBF、rCBV、rMMF和GCS评分与对照组比较有明显改善[(43.7±13.4)mL/(100g. min)比(35.5±14.8)mL/(100g.min),(3.2±0.6)mL/100g比(2.3±0.7)mL/100g,(4.5±0.9)s比(6.1±0.7)s, (11.23±1.55)分比(8.96±1.41)分,P均<0.05].结论 芳香开窍药经鼻给药能提高脑损伤后昏迷患者的脑血流速度,改善脑损伤区脑血流量,有较好的促醒作用.
目的 研究芳香開纖藥經鼻給藥對腦損傷後意識障礙患者腦血流速度及腦血流量的影響,併觀察其促囌醒作用.方法 60例腦損傷後意識障礙患者隨機分為治療組、對照組,各30例,兩組均給予常規促醒治療,治療組在常規治療的基礎上加用芳香開纖藥經鼻給藥治療.兩組治療前後均行經顱多普勒腦血管超聲檢測患者大腦中動脈(MCA)、基底動脈(BA)平均血流速度,對腦損傷區進行CT灌註成像掃描(CTPI).治療前後行Glasgow昏迷評分(GCS)進行療效評定.結果 治療1箇月後,治療組大腦中動脈(MCA)及基底動脈(BA)平均血流速度均快于對照組[(93.65± 9.71)cm/s比(81.43±9.52)cm/s),P<0.05;(37.23±5.42)cm/s比(31.52±4.12)cm/s,P<0.05].治療後治療組CTPI參數rCBF、rCBV、rMMF和GCS評分與對照組比較有明顯改善[(43.7±13.4)mL/(100g. min)比(35.5±14.8)mL/(100g.min),(3.2±0.6)mL/100g比(2.3±0.7)mL/100g,(4.5±0.9)s比(6.1±0.7)s, (11.23±1.55)分比(8.96±1.41)分,P均<0.05].結論 芳香開纖藥經鼻給藥能提高腦損傷後昏迷患者的腦血流速度,改善腦損傷區腦血流量,有較好的促醒作用.
목적 연구방향개규약경비급약대뇌손상후의식장애환자뇌혈류속도급뇌혈류량적영향,병관찰기촉소성작용.방법 60례뇌손상후의식장애환자수궤분위치료조、대조조,각30례,량조균급여상규촉성치료,치료조재상규치료적기출상가용방향개규약경비급약치료.량조치료전후균행경로다보륵뇌혈관초성검측환자대뇌중동맥(MCA)、기저동맥(BA)평균혈류속도,대뇌손상구진행CT관주성상소묘(CTPI).치료전후행Glasgow혼미평분(GCS)진행료효평정.결과 치료1개월후,치료조대뇌중동맥(MCA)급기저동맥(BA)평균혈류속도균쾌우대조조[(93.65± 9.71)cm/s비(81.43±9.52)cm/s),P<0.05;(37.23±5.42)cm/s비(31.52±4.12)cm/s,P<0.05].치료후치료조CTPI삼수rCBF、rCBV、rMMF화GCS평분여대조조비교유명현개선[(43.7±13.4)mL/(100g. min)비(35.5±14.8)mL/(100g.min),(3.2±0.6)mL/100g비(2.3±0.7)mL/100g,(4.5±0.9)s비(6.1±0.7)s, (11.23±1.55)분비(8.96±1.41)분,P균<0.05].결론 방향개규약경비급약능제고뇌손상후혼미환자적뇌혈류속도,개선뇌손상구뇌혈류량,유교호적촉성작용.
Objective To investigate the effect of aromatic resuscitation drug via nasal administrationon cerebral blood flow velocity and cerebralbloodflow in comatose patients with brain injuryand the effect on promoting patients awakening from coma. Methods Sixty unconscious patients with brain injury were randomly assigned to treatment group(n=30) and control group(n=30). The patients in control group were treated routinely. Besides routine therapy the patients in treatment group were treated with aromatic resuscitation drug through nasal administration. Mean flow rates of middle cerebral artery(MCA) and of basilar artery(BA) were determined by transcranial Doppler ul-trasound before and after treatment. CT perfusion imaging (CTPI) wasperformed inbrain injury areas. Glasgow scale (GCS) was used to evaluate the curative effect after treatment. Results After 1-month treatment, the mean flow rates of MCA and of BA intreatment group were faster than that ofcontrol group (93.65 ±9.71cm/s vs 81.43 ±9.52;37.23±5.42cm/s; all P<0.05). Test results showed improvement in CTPI in treatment group compared with control group (rCBF:43.7 ±13.4mL/(100g·min) vs 35.5 ±14.8mL/(100g·min); rCBV: 3.2 ±0.6mL/100g vs 2.3 ±0.7mL/100g;rMTT: 4.5±0.9s vs 6.1±0.7s; all P<0.05). After treatmentthe GCS score in treatment group was higher than that of control group (11.23±1.55 vs 8.96±1.41, P<0.05). Conclusion Aromatic resuscitation drug via nasal administration can improve the cerebral blood flow velocity and cerebralbloodflow in comatose patients with brain injury, and it can promote those patients awakening from coma.
