浙江中西医结合杂志
浙江中西醫結閤雜誌
절강중서의결합잡지
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
2015年
11期
1006-1009,1013
,共5页
王晓明%陈斌%林松庆%李西海
王曉明%陳斌%林鬆慶%李西海
왕효명%진빈%림송경%리서해
骨关节炎%肾阳虚%银质针%热罨包
骨關節炎%腎暘虛%銀質針%熱罨包
골관절염%신양허%은질침%열엄포
osteoarthritis%kidney-yang deficiency%silver needle%heat foment package
目的 观察银质针导热配合热罨包外敷治疗肾阳虚型膝骨关节炎的临床疗效.方法 选择膝骨关节炎患者150例,抽签法随机分为三组,观察组50例采用银质针导热疗法配合热罨包外敷,对照1组50例采用银质针导热疗法,对照2组50例采用透明质酸钠关节腔内注射.5周后,观察各组治疗前后HSS膝关节评分及关节滑液中IL-1β、IL-6、INF-α的变化.结果 各组患者膝关节疼痛评分、功能评分、活动度评分、稳定性评分、屈曲畸形评分及总评分治疗后较治疗前明显提高,治疗后观察组疼痛评分[(25.50±2.90)分比(23.20±2.99)分、(21.30±3.16)分,P<0.05]、屈曲畸形评分[(9.28±0.97)分比(8.76±1.25)分、(8.08±1.18)分,P<0.05]、总评分[(87.60±6.14)分比(83.60± 5.56)分、(77.20±7.37)分,P<0.05]明显高于两对照组;各组治疗后关节液中IL-1β、IL-6、TNF-α含量明显低于治疗前(P均<0.01);其中治疗后观察组IL-1β[(0.030±0.004)ng/mL比(0.038±0.005)ng/mL、(0.044 ±0.006)ng/mL,P<0.05]、TNF-α[(4.80 ±0.56)ng/mL比(5.03 ±0.56)ng/mL、(5.26 ±0.51)ng/mL,P<0.05]明显低于两对照组(P<0.01),对照1组又低于对照2组(P<0.05).观察组与对照1组的IL-6低于对照2组(P<0.05).结论 银质针导热疗法配合热罨包外敷的综合疗法能有效缓解肾阳虚型膝骨关节炎患者的临床症状.
目的 觀察銀質針導熱配閤熱罨包外敷治療腎暘虛型膝骨關節炎的臨床療效.方法 選擇膝骨關節炎患者150例,抽籤法隨機分為三組,觀察組50例採用銀質針導熱療法配閤熱罨包外敷,對照1組50例採用銀質針導熱療法,對照2組50例採用透明質痠鈉關節腔內註射.5週後,觀察各組治療前後HSS膝關節評分及關節滑液中IL-1β、IL-6、INF-α的變化.結果 各組患者膝關節疼痛評分、功能評分、活動度評分、穩定性評分、屈麯畸形評分及總評分治療後較治療前明顯提高,治療後觀察組疼痛評分[(25.50±2.90)分比(23.20±2.99)分、(21.30±3.16)分,P<0.05]、屈麯畸形評分[(9.28±0.97)分比(8.76±1.25)分、(8.08±1.18)分,P<0.05]、總評分[(87.60±6.14)分比(83.60± 5.56)分、(77.20±7.37)分,P<0.05]明顯高于兩對照組;各組治療後關節液中IL-1β、IL-6、TNF-α含量明顯低于治療前(P均<0.01);其中治療後觀察組IL-1β[(0.030±0.004)ng/mL比(0.038±0.005)ng/mL、(0.044 ±0.006)ng/mL,P<0.05]、TNF-α[(4.80 ±0.56)ng/mL比(5.03 ±0.56)ng/mL、(5.26 ±0.51)ng/mL,P<0.05]明顯低于兩對照組(P<0.01),對照1組又低于對照2組(P<0.05).觀察組與對照1組的IL-6低于對照2組(P<0.05).結論 銀質針導熱療法配閤熱罨包外敷的綜閤療法能有效緩解腎暘虛型膝骨關節炎患者的臨床癥狀.
목적 관찰은질침도열배합열엄포외부치료신양허형슬골관절염적림상료효.방법 선택슬골관절염환자150례,추첨법수궤분위삼조,관찰조50례채용은질침도열요법배합열엄포외부,대조1조50례채용은질침도열요법,대조2조50례채용투명질산납관절강내주사.5주후,관찰각조치료전후HSS슬관절평분급관절활액중IL-1β、IL-6、INF-α적변화.결과 각조환자슬관절동통평분、공능평분、활동도평분、은정성평분、굴곡기형평분급총평분치료후교치료전명현제고,치료후관찰조동통평분[(25.50±2.90)분비(23.20±2.99)분、(21.30±3.16)분,P<0.05]、굴곡기형평분[(9.28±0.97)분비(8.76±1.25)분、(8.08±1.18)분,P<0.05]、총평분[(87.60±6.14)분비(83.60± 5.56)분、(77.20±7.37)분,P<0.05]명현고우량대조조;각조치료후관절액중IL-1β、IL-6、TNF-α함량명현저우치료전(P균<0.01);기중치료후관찰조IL-1β[(0.030±0.004)ng/mL비(0.038±0.005)ng/mL、(0.044 ±0.006)ng/mL,P<0.05]、TNF-α[(4.80 ±0.56)ng/mL비(5.03 ±0.56)ng/mL、(5.26 ±0.51)ng/mL,P<0.05]명현저우량대조조(P<0.01),대조1조우저우대조2조(P<0.05).관찰조여대조1조적IL-6저우대조2조(P<0.05).결론 은질침도열요법배합열엄포외부적종합요법능유효완해신양허형슬골관절염환자적림상증상.
Objective To investigate the clinical efficacy of thermal conductivity of silver needle combined with external application of heat foment package in the treatment of kidney-yang deficiency type of knee osteoarthritis. Methods One hundred and fifty patients with knee osteoarthritis were randomly divided into 3 groups: observation group receiving thermal conductivity of silver needle combined with external application of heat foment package(n=50), control group 1 with thermal treatment of silver needle(n=50), and control group 2 with intra-articular injec-tion of sodium hyaluronate (n=50). After 5-week treatment, each group was observed HSS knee score and the change of IL-1β, IL-6, TNF-α levels in synovial fluid before and after treatment. Results After treatment, pain score, function score, activity score and total score of knee in each groupwas significantly higher than that before treatment; among these scores, pain score, flexion deformity and total score in observation group were significantly higher then that of control group 1 and 2 (25.50±2.90 vs 23.20±2.99 and 21.30±3.16; 9.28±0.97 vs 8.76±1.25 and 8.08±1.18; 87.60±6.14 vs 83.60±5.56 and 77.20±7.37; P<0.05, P<0.01). The IL-1β, IL-6, TNF-α levels in syn-ovial fluid of each group were significantly different before and after treatment(all P<0.01). After treatment the lev-els of IL-1β and TNF-α of the observation group were significantly lower than those of control group 1 and 2 (0.030 ±0.004ng/mL vs 0.038 ±0.005ng/mL and 0.044 ±0.006ng/mL; 4.80 ±0.56ng/mL vs 5.03 ±0.56ng/mL and 5.26 ± 0.51ng/mL; P<0.01) and control group 1 was significantly lower than those of control group 2(P<0.05). Conclusion The thermal conductivity of silver needle combined with external applicationof heat foment package could effec-tively alleviate the clinical symptoms of kidney-yang deficiency type of knee osteoarthritis.
