医学综述
醫學綜述
의학종술
Medical Recapitulate
2015年
21期
3905-3907,3908
,共4页
刘俊勇(综述)%彭芳(审校)
劉俊勇(綜述)%彭芳(審校)
류준용(종술)%팽방(심교)
肿瘤%耐药%动物模型%移植型%诱导型%评价方法
腫瘤%耐藥%動物模型%移植型%誘導型%評價方法
종류%내약%동물모형%이식형%유도형%평개방법
Tumor%Resistance%Animal model%Transplantation%Induction%Evaluation method
多药耐药性( MDR)肿瘤动物模型是攻克肿瘤耐药性的基础,同时在逆转肿瘤耐药性的药物筛选研究中也起重要作用,因此,优越的MDR肿瘤动物模型在科学研究中具有很高的应用价值。目前,MDR肿瘤动物模型主要通过移植、诱导和体内外联合诱导3种方法构建。该文通过对MDR肿瘤动物模型资料进行归纳和总结,对这3种方法进行了详细的表述和评价,并对MDR肿瘤动物模型的评价方法进行了简要的叙述。
多藥耐藥性( MDR)腫瘤動物模型是攻剋腫瘤耐藥性的基礎,同時在逆轉腫瘤耐藥性的藥物篩選研究中也起重要作用,因此,優越的MDR腫瘤動物模型在科學研究中具有很高的應用價值。目前,MDR腫瘤動物模型主要通過移植、誘導和體內外聯閤誘導3種方法構建。該文通過對MDR腫瘤動物模型資料進行歸納和總結,對這3種方法進行瞭詳細的錶述和評價,併對MDR腫瘤動物模型的評價方法進行瞭簡要的敘述。
다약내약성( MDR)종류동물모형시공극종류내약성적기출,동시재역전종류내약성적약물사선연구중야기중요작용,인차,우월적MDR종류동물모형재과학연구중구유흔고적응용개치。목전,MDR종류동물모형주요통과이식、유도화체내외연합유도3충방법구건。해문통과대MDR종류동물모형자료진행귀납화총결,대저3충방법진행료상세적표술화평개,병대MDR종류동물모형적평개방법진행료간요적서술。
Multidrug resistant( MDR) tumor animal model is fundamental to overcome tumor resistance , which also plays a crucial role in the drug screening study about effectively reversing drug resistance in a variety of tumors,therefore,the value of superior MDR animal model is even more prominent in scientific research.So far,transplantation,induction and combination of in vitro and in vivo induction ,are three meth-ods to build the MDR tumor animal models .Here is to summarize the data about MDR tumor animal models , and the three methods are described and evaluated in detail , the evaluation method of MDR tumor animal models is briefly described as well.