医学综述
醫學綜述
의학종술
Medical Recapitulate
2015年
21期
3886-3889
,共4页
那晶(综述)%汤小晗%卢美松(审校)
那晶(綜述)%湯小晗%盧美鬆(審校)
나정(종술)%탕소함%로미송(심교)
卵母细胞%卵泡液%蛋白组学%代谢组学
卵母細胞%卵泡液%蛋白組學%代謝組學
란모세포%란포액%단백조학%대사조학
Oocytes%Follicular fluid%Proteomics%Metabonomics
在辅助生殖治疗过程中,正确评估卵母细胞的质量对于治疗结局具有重要意义。对卵母细胞质量的评估方法有许多种,卵泡液获取方便,是目前对卵母细胞质量评估的最理想非侵入性指标。所以,卵泡液因子在评估卵母细胞质量中备受关注。大量研究表明,卵泡液中的甾体激素水平、促性腺激素水平及卵泡液中一些细胞因子均与卵母细胞质量具有相关性。近年来,卵泡液蛋白组学、代谢组学的研究成为主要趋势,也有望成为卵母细胞评估的重要工具。
在輔助生殖治療過程中,正確評估卵母細胞的質量對于治療結跼具有重要意義。對卵母細胞質量的評估方法有許多種,卵泡液穫取方便,是目前對卵母細胞質量評估的最理想非侵入性指標。所以,卵泡液因子在評估卵母細胞質量中備受關註。大量研究錶明,卵泡液中的甾體激素水平、促性腺激素水平及卵泡液中一些細胞因子均與卵母細胞質量具有相關性。近年來,卵泡液蛋白組學、代謝組學的研究成為主要趨勢,也有望成為卵母細胞評估的重要工具。
재보조생식치료과정중,정학평고란모세포적질량대우치료결국구유중요의의。대란모세포질량적평고방법유허다충,란포액획취방편,시목전대란모세포질량평고적최이상비침입성지표。소이,란포액인자재평고란모세포질량중비수관주。대량연구표명,란포액중적치체격소수평、촉성선격소수평급란포액중일사세포인자균여란모세포질량구유상관성。근년래,란포액단백조학、대사조학적연구성위주요추세,야유망성위란모세포평고적중요공구。
During the treatment of assisted reproduction ,it is very important for the treatment outcomes to correctly evaluate the quality of oocytes.There are many kinds of methods for the evaluation of quality of oocytes,since the extraction of follicular fluid could be easily acquired ,it is currently the most ideal non-inva-sive index for evaluation of oocytes quality.Therefore,follicular fluid factors have got much attention in the evaluation of oocytes quality.A large number of studies showed that the levels of steroid hormone ,gonadotro-pin and some cytokines in the follicular fluid are associated with the quality of oocytes .In recent years,pro-teomics of follicular fluid and metabonomics have become a major trend , which hopefully will become an important tool for oocytes evaluation.