CAJ | 학술논문

转运系统A载体——钠离子依赖性的中性氨基酸转运载体2 ( SNAT2 )是近年发现的氨基酸转运感受体的典型代表,是体内主要的氮转运载体. SNAT2通过转运过程调节细胞内氨基酸浓度,进而调控细胞内氨基酸感受体的下游信号,发挥氨基酸转运载体和信号受体的双重功能,而成为近年氨基酸营养感应的研究热点. 本文围绕SNAT2的分子特性、生物学特性、表达调控及其介导的氨基酸感应信号的研究进展进行综述.
전운계통A재체——납리자의뢰성적중성안기산전운재체2 ( SNAT2 )시근년발현적안기산전운감수체적전형대표,시체내주요적담전운재체. SNAT2통과전운과정조절세포내안기산농도,진이조공세포내안기산감수체적하유신호,발휘안기산전운재체화신호수체적쌍중공능,이성위근년안기산영양감응적연구열점. 본문위요SNAT2적분자특성、생물학특성、표체조공급기개도적안기산감응신호적연구진전진행종술.
Sodium-dependent neutral amino acid transporter 2 ( SNAT2 ) , which belongs to transport system A,is the main transporter of nitrogen in vivo. SNAT2 is well known as typical amino acid transceptor founded in recent years, which plays a dual role of amino acid transporter and receptor through regulating the concentra-tion of intracellular amino acids, thereby regulating the downstream signal of intracellular amino acid receptors. Because of its unique features, SNAT2 has become an attractive topic in nutritional induction of amino acids in recent years. In the present review, the new research progresses on the molecular characteristics, biological properties, expression regulation and amino acids sensing signaling of SNAT2 were summarized.