当代医学
噹代醫學
당대의학
Contemporary Medicine
2015年
33期
1-2,3
,共3页
李晓英%陈丽娟%郭惠萍%强萍
李曉英%陳麗娟%郭惠萍%彊萍
리효영%진려연%곽혜평%강평
反复自然流产%亚甲基四氢叶酸还原酶%蛋氨酸合成酶还原酶%多态性%易感性
反複自然流產%亞甲基四氫葉痠還原酶%蛋氨痠閤成酶還原酶%多態性%易感性
반복자연유산%아갑기사경협산환원매%단안산합성매환원매%다태성%역감성
Recurrent spontaneous abortion%Methylenetetrahydrofolate reductase%Methionine synthase reductase%Polymorphism%Susceptibility
目的:探讨叶酸代谢酶关键酶基因多态性与反复自然性流产的易感性。方法采用基因测序技术检测60例反复自然性流产和150例正常妊娠的妇女亚甲基四氢叶酸还原酶 MTHFR C 677 T、A 1298 C 和甲硫氨酸合酶还原酶 MTRR A 66 G 的基因多态性。结果流产组 MTHFR C 677 T 等位基因频率中 T 所占比率30.0%(36/120)明显高于对照组21.3%(64/300)(P<0.05);自然性流产组 MTHFR A 1298 C 基因型频率中 CC 所占比率13.3%(8/60)高于对照组3.3%(5/150)(P<0.05);等位基因频率中 C 所占比率35.8%(43/120)明显高于对照组24.7%(74/300)(P<0.05);MTRR A 66 G 基因等位基因频率中 G 所占比率33.3%(40/120)明显高于对照组25.3%(76/300)(P<0.05)。结论与正常妊娠的妇女比较,反复自然性流产妇女的MTHFR 基因A 1298 C、C 677 T 两个位点和MTRR A 66 G 位点基因的突变基因频率明显增加,MTHFR 基因和MTRR 基因的多态性的检测可作为反复自然流产患者的临床诊断指标。
目的:探討葉痠代謝酶關鍵酶基因多態性與反複自然性流產的易感性。方法採用基因測序技術檢測60例反複自然性流產和150例正常妊娠的婦女亞甲基四氫葉痠還原酶 MTHFR C 677 T、A 1298 C 和甲硫氨痠閤酶還原酶 MTRR A 66 G 的基因多態性。結果流產組 MTHFR C 677 T 等位基因頻率中 T 所佔比率30.0%(36/120)明顯高于對照組21.3%(64/300)(P<0.05);自然性流產組 MTHFR A 1298 C 基因型頻率中 CC 所佔比率13.3%(8/60)高于對照組3.3%(5/150)(P<0.05);等位基因頻率中 C 所佔比率35.8%(43/120)明顯高于對照組24.7%(74/300)(P<0.05);MTRR A 66 G 基因等位基因頻率中 G 所佔比率33.3%(40/120)明顯高于對照組25.3%(76/300)(P<0.05)。結論與正常妊娠的婦女比較,反複自然性流產婦女的MTHFR 基因A 1298 C、C 677 T 兩箇位點和MTRR A 66 G 位點基因的突變基因頻率明顯增加,MTHFR 基因和MTRR 基因的多態性的檢測可作為反複自然流產患者的臨床診斷指標。
목적:탐토협산대사매관건매기인다태성여반복자연성유산적역감성。방법채용기인측서기술검측60례반복자연성유산화150례정상임신적부녀아갑기사경협산환원매 MTHFR C 677 T、A 1298 C 화갑류안산합매환원매 MTRR A 66 G 적기인다태성。결과유산조 MTHFR C 677 T 등위기인빈솔중 T 소점비솔30.0%(36/120)명현고우대조조21.3%(64/300)(P<0.05);자연성유산조 MTHFR A 1298 C 기인형빈솔중 CC 소점비솔13.3%(8/60)고우대조조3.3%(5/150)(P<0.05);등위기인빈솔중 C 소점비솔35.8%(43/120)명현고우대조조24.7%(74/300)(P<0.05);MTRR A 66 G 기인등위기인빈솔중 G 소점비솔33.3%(40/120)명현고우대조조25.3%(76/300)(P<0.05)。결론여정상임신적부녀비교,반복자연성유산부녀적MTHFR 기인A 1298 C、C 677 T 량개위점화MTRR A 66 G 위점기인적돌변기인빈솔명현증가,MTHFR 기인화MTRR 기인적다태성적검측가작위반복자연유산환자적림상진단지표。
Objective To investigate the susceptibility between a key enzyme in folate metabolism enzyme and recurrent spontaneous abortion. Methods The genetic polymorphisms of MTHFR C 677 T, MTHFR A 1298 C and MT RR A 66 G in 60 cases of recurrent spontaneous abortion and 150 normal pregnant women were detected using gene sequencing technology. Results MTHFR C 677 T T allele frequency in percentage in natural abortion group 30.0% (36/120) was significantly higher than that in the control group 21.3% (64/300) (P <0.05); MTHFR A 1298 C CC genotype frequency percentage in natural abortion group 13.3% (8/60) was higher than that in the control group 3.3% (5/150) (P <0.05); C allele frequency percentage 35.8% (43/120) was significantly higher than that in the control group 24.7% (74/300) (P <0.05); MTRR A 66 G Allelism G gene frequency percentage in natural abortion group 33.3% (40/120) was significantly higher than that in the control group 25.3% (76/300) (P <0.05). Conclusion Compared with normal pregnancy women, MTHFR gene A 1298 C, C 677 T and MTRR A 66 G frequency increased in recurrent spontaneous abortion patients, it can be as recurrent spontaneous abortion patients with clinical diagnostic criteria.