CAJ | 학술논문

目的：探讨雷替曲塞腹腔灌注化疗在手术治疗局部进展期贲门癌中的应用价值。方法根据治疗方法不同将进展期贲门癌患者60例分为2组，治疗组30例行手术治疗并在术中腹腔灌注雷替曲塞，对照组30例给予常规手术治疗。观察2组术前及术后白细胞计数、肝肾功能、细胞免疫指标变化，统计2组胸腔引流时间及胃肠道功能恢复时间，比较2组围术期并发症及不良反应发生情况，随访2组1，3，5年生存率。结果2组术前及术后白细胞计数、肝肾功能及各项细胞免疫指标比较差异均无统计学意义（ P均＞0．05）；术后2组胸腔引流时间、胃肠道功能恢复时间、并发症及不良反应发生率比较差异均无统计学意义（P均＞0．05），治疗组1，3，5年生存率均明显高于对照组（P均＜0．05）。结论雷替曲塞术中腹腔灌注化疗能够提高局部进展期贲门癌患者的长期生存率，且安全性高，值得推广应用。
목적：탐토뢰체곡새복강관주화료재수술치료국부진전기분문암중적응용개치。방법근거치료방법불동장진전기분문암환자60례분위2조，치료조30례행수술치료병재술중복강관주뢰체곡새，대조조30례급여상규수술치료。관찰2조술전급술후백세포계수、간신공능、세포면역지표변화，통계2조흉강인류시간급위장도공능회복시간，비교2조위술기병발증급불량반응발생정황，수방2조1，3，5년생존솔。결과2조술전급술후백세포계수、간신공능급각항세포면역지표비교차이균무통계학의의（ P균＞0．05）；술후2조흉강인류시간、위장도공능회복시간、병발증급불량반응발생솔비교차이균무통계학의의（P균＞0．05），치료조1，3，5년생존솔균명현고우대조조（P균＜0．05）。결론뢰체곡새술중복강관주화료능구제고국부진전기분문암환자적장기생존솔，차안전성고，치득추엄응용。
Objective It is to investigate the application value of raltitrexed intraperitoneal perfusion chemotherapy during operation of advanced gastric cardial carcinoma .Methods 60 patients with local advanced gastric cardial carcinoma were di-vided into two groups according to the treatment method , 30 cases in treatment group were treated with raltitrexed intraperitone-al perfusion chemotherapy during the radical operation , whereas the remaining 30 cases in control group underwent surgical treatment only.The liver and kidney functions , WBC, immunity index which measured on the 1 day of pre-operation and the 7th day of post-operation respectively were compared .The time of abdominal drainage and gastrointestinal function recovery in the two groups were observed .The other aspects such as the operative complication , the toxicity of chemotherapy , and the mortality and survival rate between these two groups were compared .Results There were no significant differences in liver and kidney functions , WBC and immunity index between the two groups in pre-operation and post-operation ( all P>0 .05 );and there were no significant differences in the operative complication incidence , the toxicity of chemotherapy between the two groups (all P>0.05).The survival rate of 1-, 3-, 5-year in the treatment group were markedly higher than those in the control group (all P<0.05).Conclusion Raltitrexed intrapertioneal perfusion chemotherapy during operation can improve the long-term survival rate of patients with local gastric cardial cancer , it is safe, and is worthy of popularization and application .