医学信息
醫學信息
의학신식
Medical Information
2015年
45期
419-420
,共2页
韩松%阮建山%丁仲杰%俞秋雁
韓鬆%阮建山%丁仲傑%俞鞦雁
한송%원건산%정중걸%유추안
卡培他滨片%高效液相色谱法%含量测定
卡培他濱片%高效液相色譜法%含量測定
잡배타빈편%고효액상색보법%함량측정
Capecitabine tablets%HPLC%Assay
目的:建立HPLC法测定卡培他滨片中卡培他滨含量的方法。方法色谱柱为Inertsil ODS-3(250mm×4.6mm,5μm);以甲醇-乙腈-0.1%醋酸溶液(7:1:12)为流动相A,以甲醇-乙腈-0.1%醋酸溶液(16:1:3)为流动相B,梯度洗脱;流速为1.0ml/min,检测波长为250nm,柱温为40℃;外标法。结果本方法在0.36~0.84mg/ml浓度范围内线性良好(r=1),定量限为1.2ng。结论本方法灵敏度高、专属性好、准确度高,适用于卡培他滨片中卡培他滨的含量测定。
目的:建立HPLC法測定卡培他濱片中卡培他濱含量的方法。方法色譜柱為Inertsil ODS-3(250mm×4.6mm,5μm);以甲醇-乙腈-0.1%醋痠溶液(7:1:12)為流動相A,以甲醇-乙腈-0.1%醋痠溶液(16:1:3)為流動相B,梯度洗脫;流速為1.0ml/min,檢測波長為250nm,柱溫為40℃;外標法。結果本方法在0.36~0.84mg/ml濃度範圍內線性良好(r=1),定量限為1.2ng。結論本方法靈敏度高、專屬性好、準確度高,適用于卡培他濱片中卡培他濱的含量測定。
목적:건립HPLC법측정잡배타빈편중잡배타빈함량적방법。방법색보주위Inertsil ODS-3(250mm×4.6mm,5μm);이갑순-을정-0.1%작산용액(7:1:12)위류동상A,이갑순-을정-0.1%작산용액(16:1:3)위류동상B,제도세탈;류속위1.0ml/min,검측파장위250nm,주온위40℃;외표법。결과본방법재0.36~0.84mg/ml농도범위내선성량호(r=1),정량한위1.2ng。결론본방법령민도고、전속성호、준학도고,괄용우잡배타빈편중잡배타빈적함량측정。
Objective To establish an HPLC method for the determination of capecitabine in capecitabine tablets.Methods The chromatographic column was Inertsil ODS-3(250mmí4.6mm,5μm)with gradient elution,methanol-acetonitrile-0.1%glacial acetic solution(7:1:12) as the mobile phase A and methanol-acetonitrile-0.1%glacial acetic solution(16:1:3) as the mobile phase B at the flow rate of 1.0 ml/min,the detective wavelength was 250nm and the temperature of column was 40℃.Results The linear range of capecitabine was 0.36~0.84 mg/ml (r=1).The limit of quantification was 1.2ng. Conclusion The method is sensitive,selective,accutate and be used for the determination of capecitabine in capecitabine tablets.