CAJ | 학술논문

目的探究难治性抑郁症患者接受艾司西酞普兰联合奎硫平进行治疗的临床效果及安全性. 方法将本院近4年来门诊及住院收治难治性抑郁症患者为本次研究对象,随机抽取78例并根据治疗方案对其进行分组并对照研究,对照组患者38例,接受艾司西酞普兰治疗,观察组患者40例,在对照组治疗基础上联合奎硫平治疗. 对比2组患者不良心理状况改善程度及不良反应情况. 结果分别在患者治疗前、治疗后1 周末、4 周末及6 周末对患者心理状况用汉密尔顿抑郁量表( HAMD)以及汉密尔顿焦虑量表( HAMA)进行检测,2 组患者均有所改善,观察组患者改善程度显著优于对照组,差异有统计学意义(P<0.05);2组患者均出现轻微不良反应,均未接受特殊处理即逐渐缓解,对比无统计学意义(P>0.05). 结论对难治性抑郁症患者应用艾司西酞普兰联合奎硫平方案治疗能够取得令人满意的临床疗效,值得临床普及推广.
목적 탐구난치성억욱증환자접수애사서태보란연합규류평진행치료적림상효과급안전성. 방법 장본원근4년래문진급주원수치난치성억욱증환자위본차연구대상,수궤추취78례병근거치료방안대기진행분조병대조연구,대조조환자38례,접수애사서태보란치료,관찰조환자40례,재대조조치료기출상연합규류평치료. 대비2조환자불양심리상황개선정도급불량반응정황. 결과 분별재환자치료전、치료후1 주말、4 주말급6 주말대환자심리상황용한밀이돈억욱량표( HAMD)이급한밀이돈초필량표( HAMA)진행검측,2 조환자균유소개선,관찰조환자개선정도현저우우대조조,차이유통계학의의(P<0.05);2조환자균출현경미불량반응,균미접수특수처리즉축점완해,대비무통계학의의(P>0.05). 결론 대난치성억욱증환자응용애사서태보란연합규류평방안치료능구취득령인만의적림상료효,치득림상보급추엄.
Objective To explore the refractory depression patients receiving escitalopram combined with quetiapine in the treatment of clinical efficacy and safety of.Methods Included in our hospital in recent years were refractory depression patients as the research object ,randomly selected 78 cases and according to the regimen in the treatment of the grouping and control study,control group(38 cases),acceptance of escitalopram in the treatment of observed group were 40 cases,in the control group on the basis of the treatment combined with quetiapine .In the 2 groups of patients in the heart to improve the degree of improvement and adverse reactions .Results The psychological status of patients were measured by Hamilton Depression Rating Scale(HAMD)and Hamilton Anxiety Scale(HAMA)before and after treatment for 1 weeks,4 weeks and 6 weeks,respectively.The improvement of the 2 groups was significantly better than that in the control group,the difference was statistically signifi-cant(P <0.05),and the 2 groups had no special treatment.Conclusion The refractory depression patients were treated with escitalopram combined with quetiapine square case treatment can achieve satisfactory clinical efficacy,worthy of clinical popularization.