CAJ | 학술논문

高原低氧适应是高原医学研究的核心，高原低氧适应的机制主要是围绕缺氧而建立起的一系列复杂的代偿。高原土生动物是研究高原低氧适应的理想模型，以藏猪、高原鼠兔、藏羚羊和蕨麻小型猪为例，研究者们多以其血液学特征、肺血管结构和功能及低氧适应相关基因等方面作为基础研究，但目前在细胞及分子水平研究不够深入，研究土生动物低氧适应机制，可以为高原实验动物的开发研究提供理论基础。
고원저양괄응시고원의학연구적핵심，고원저양괄응적궤제주요시위요결양이건립기적일계렬복잡적대상。고원토생동물시연구고원저양괄응적이상모형，이장저、고원서토、장령양화궐마소형저위례，연구자문다이기혈액학특정、폐혈관결구화공능급저양괄응상관기인등방면작위기출연구，단목전재세포급분자수평연구불구심입，연구토생동물저양괄응궤제，가이위고원실험동물적개발연구제공이론기출。
Plateau hypoxia adaptation is the core of the plateau medical research , the mechanism of which is mainly a series of complex compensatory established around the hypoxia .Native plateau animals are ideal models of plateau hypoxia adaptation research.Based on the Tibetan pig,plateau pika,the Tibetan ante-lope and Juema minipig,researchers conducted basic research on their characteristics of hematology,pulmo-nary vascular structure and function,hypoxia adaptation related genes,etc.,but there is not enough research on the cellular and molecular level.Research on native plateau animals of hypoxia adaptation mechanisms can provide theoretical basis for the study and development of the plateau experimental animals .