江苏科技信息
江囌科技信息
강소과기신식
Jiangsu Science & Technology Information
2015年
30期
73-76
,共4页
赵倩%迪力夏提·金斯汗%李涌涛%朱丽萍
趙倩%迪力夏提·金斯汗%李湧濤%硃麗萍
조천%적력하제·금사한%리용도%주려평
乳腺癌%早发性%三阴性%BRCA1/2基因%DNA测序
乳腺癌%早髮性%三陰性%BRCA1/2基因%DNA測序
유선암%조발성%삼음성%BRCA1/2기인%DNA측서
breast cancer%early onset three negative%BRCA 1/2 gene%DNA sequence analysis
文章通过检测新疆地区汉族及维吾尔族三阴性乳腺癌中Brca1/2基因突变情况,探讨Brca1/2基因与三阴性乳腺癌的关系。文章选取病理确诊三阴性乳腺癌88例(汉族63例,维吾尔族25例)标本,运用聚合酶链反应方法(PCR)和DNA测序检测Brca1/2基因突变,并结合临床及病理因素进行分析。结果显示:88例患者中BRCA1/2突变25例,19例BRCA1突变,6例BRCA2突变;汉族18例、维吾尔族7例;77例为绝经前患者,BRCA1/2基因突变23例,11例为绝经后患者,BRCA1/2基因突变2例;早发性乳腺癌(年龄≤35岁)26例,BRCA1突变5例,BRCA2突变3例,年龄>35岁乳腺癌患者62例, BRCA1突变14例,BRCA2突变3例,两组患者突变情况经比较,差异均无统计学意义(P>0.05)。最终得出结论,选择性三阴性乳腺癌患者BRCA1/2突变率更高,绝经前的三阴性乳腺癌患者尤其是年龄在35岁以下的选择性乳腺癌患者建议进行BRCA1/2突变检测。
文章通過檢測新疆地區漢族及維吾爾族三陰性乳腺癌中Brca1/2基因突變情況,探討Brca1/2基因與三陰性乳腺癌的關繫。文章選取病理確診三陰性乳腺癌88例(漢族63例,維吾爾族25例)標本,運用聚閤酶鏈反應方法(PCR)和DNA測序檢測Brca1/2基因突變,併結閤臨床及病理因素進行分析。結果顯示:88例患者中BRCA1/2突變25例,19例BRCA1突變,6例BRCA2突變;漢族18例、維吾爾族7例;77例為絕經前患者,BRCA1/2基因突變23例,11例為絕經後患者,BRCA1/2基因突變2例;早髮性乳腺癌(年齡≤35歲)26例,BRCA1突變5例,BRCA2突變3例,年齡>35歲乳腺癌患者62例, BRCA1突變14例,BRCA2突變3例,兩組患者突變情況經比較,差異均無統計學意義(P>0.05)。最終得齣結論,選擇性三陰性乳腺癌患者BRCA1/2突變率更高,絕經前的三陰性乳腺癌患者尤其是年齡在35歲以下的選擇性乳腺癌患者建議進行BRCA1/2突變檢測。
문장통과검측신강지구한족급유오이족삼음성유선암중Brca1/2기인돌변정황,탐토Brca1/2기인여삼음성유선암적관계。문장선취병리학진삼음성유선암88례(한족63례,유오이족25례)표본,운용취합매련반응방법(PCR)화DNA측서검측Brca1/2기인돌변,병결합림상급병리인소진행분석。결과현시:88례환자중BRCA1/2돌변25례,19례BRCA1돌변,6례BRCA2돌변;한족18례、유오이족7례;77례위절경전환자,BRCA1/2기인돌변23례,11례위절경후환자,BRCA1/2기인돌변2례;조발성유선암(년령≤35세)26례,BRCA1돌변5례,BRCA2돌변3례,년령>35세유선암환자62례, BRCA1돌변14례,BRCA2돌변3례,량조환자돌변정황경비교,차이균무통계학의의(P>0.05)。최종득출결론,선택성삼음성유선암환자BRCA1/2돌변솔경고,절경전적삼음성유선암환자우기시년령재35세이하적선택성유선암환자건의진행BRCA1/2돌변검측。
This paper aims to explore the relationship between triple-negative breast cancer and BRCA1/2 gene by detecting mutation of BRCA1/2 gene in Han and Uygur women with triple-negative breast cancer in Xinjiang area. This paper analysis on the pathological diagnosis in 88 cases of triple-negative breast cancer (63cases of Han,25 cases of Uygur) specimens, polymerase chain reaction(PCR)and DNA sequencing were used to detect the mutation of BRCA1/2 gene and analysis clinical pathological factors. Results display: this study shows that 25 patients was BRCA1/2 mutation in 88 cases,19 cases of BRCA1 mutation,6 cases of BRCA2;18 cases of Han,7 cases of Uygur. Addition,there were 23 cases of BRCA1/2 mutation in 77 patients who were premenopausal patients ,2 cases of BRCA1/2 mutation in 23 patients who were postmenopausal patients.And 5 cases of BRCA1 mutation,3 cases of BRCA2 mutation were in 25 patients of Early-onset breast cancer(age≤35 years),14 cases of BRCA1 mutation ,3 cases of BRCA2 mutation were in 62 patients of Breast cancer (age>35 years).Compared with two groups patients of BRCA1/2 mutation,there were no statistics difference (P>0.05). Finally come to the conclusion,selective triple-negative breast cancer get the higher mutation rate;selective triple-breast cancer of premenopausal patients is suggested to detect BRCA1/2 gene,especially age≤35 years.