CAJ | 학술논문

目的：观察复方血栓通胶囊联合羟苯磺酸钙治疗早期糖尿病性视网膜病变（ DR）患者的临床疗效及对血清高敏C反应蛋白（ hs－CRP）、血管内皮生长因子（ VEGF）和胰岛素样生长因子1（IGF－1）水平的影响。方法将64例早期DR患者随机分为观察组和对照组各32例，对照组予羟苯磺酸钙片口服，观察组在此基础上加服复方血栓通胶囊。监测2组治疗前后视野灰度值、血管瘤体积、出血斑面积、黄斑厚度及血清hs－CRP、VEGF、IGF－1水平，评价临床疗效，观察不良反应及复发情况。结果观察组总有效率明显高于对照组（P＜0.05），复发率明显低于对照组（P＜0．05）；2组治疗后视野灰度值、血管瘤体积、出血斑面积、黄斑厚度及血清hs－CRP、VEGF和IGF－1水平均较治疗前明显改善（ P均＜0．05），且观察组改善情况显著优于对照组（ P均＜0．05）。结论复方血栓通胶囊联合羟苯磺酸钙能有效改善早期DR患者视网膜状况，降低hs－CRP、VEGF和IGF－1水平，延缓血管增殖，降低复发率，值得推广应用。
목적：관찰복방혈전통효낭연합간분광산개치료조기당뇨병성시망막병변（ DR）환자적림상료효급대혈청고민C반응단백（ hs－CRP）、혈관내피생장인자（ VEGF）화이도소양생장인자1（IGF－1）수평적영향。방법장64례조기DR환자수궤분위관찰조화대조조각32례，대조조여간분광산개편구복，관찰조재차기출상가복복방혈전통효낭。감측2조치료전후시야회도치、혈관류체적、출혈반면적、황반후도급혈청hs－CRP、VEGF、IGF－1수평，평개림상료효，관찰불량반응급복발정황。결과관찰조총유효솔명현고우대조조（P＜0.05），복발솔명현저우대조조（P＜0．05）；2조치료후시야회도치、혈관류체적、출혈반면적、황반후도급혈청hs－CRP、VEGF화IGF－1수평균교치료전명현개선（ P균＜0．05），차관찰조개선정황현저우우대조조（ P균＜0．05）。결론복방혈전통효낭연합간분광산개능유효개선조기DR환자시망막상황，강저hs－CRP、VEGF화IGF－1수평，연완혈관증식，강저복발솔，치득추엄응용。
Objective It is to investigate the clinical effect and serum high-sensitivity C reactive protein ( hs-CRP) , vas-cular endothelial growth factor (VEGF) and insulin-like growth factor 1 (IGF-1) levels of Xueshuantong capsule combined with Calcium Dobesilate in treatment of early diabetic retinopathy (DR).Methods 64 patients with early DR were randomly divided into observation group (32 cases) and control group (32 cases).The control group was treated with oral calcium hy-droxide and other Western medicine .The observation group was treated with thrombus .The changes of visual field , blood ves-sel tumor, hemorrhage, macular thickness and serum VEGF , IGF-1, hs-CRP levels in patients before and after treatment were detected , and the clinical efficacy was evaluated , adverse reactions and recurrence were observed .Results The total ef-fective rate of the observation group was significantly higher while the recurrence rate was significantly lower than that in the control group(P<0.05);In the two groups, the level of visual gray value , hemangioma, bleeding spots, macular thickness were significantly improved , and the improvement of the observation group was significantly better than that of the control group (P<0.05).Conclusion Xueshuantong capsule combined with Calcium Dobesilate can improve retina and reduce the recur -rence rate, reduce the levels of hs -CRP, VEGF and IGF-1, delay the proliferation of blood vessels in the patients with DR , it is worthy of clinical promotion .