CAJ | 학술논문

目的：探索二氯甲烷暴露对家具制造工人肝功能的影响。方法选择家具制造企业上胶工人和另一企业拟上岗工人，按年龄、性别进行1∶1配对，纳入暴露组和对照组各22名工人。测定暴露工人工作场所二氯甲烷浓度，检测并比较两组工人血清总蛋白（TP）、白蛋白（ALB）、球蛋白（GloB）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、腺苷脱氨酶（ADA）、胆碱酯酶（CHE）、总胆红素（TBIL）、直接胆红素（DBIL）和间接胆红素（IBIL）等肝功能指标。结果暴露组工作场所二氯甲烷浓度为1300～7760 mg/ m3，暴露组工人血清 TP、ALB和 GloB 含量分别为（73.7±3.6）、（47.5±2.3）和（26.2±2.8）g/ L，均低于对照组的（79.2±4.2）、（49.9±3.2）和（29.2±3.3）g/ L（P ＜0.05）；暴露组工人血清 CHE、ADA、AST 和 ALT 活力水平分别为（7477.8±1240.8）、（7.3±1.7）、（21.6±5.6）和（13.0±5.6）U/ L，均低于对照组的（9523.9±2010.3）、（9.1±2.0）、（26.6±9.4）和（29.0±16.7） U/ L（ P ＜0.05）；暴露组工人血清 TBIL、DBIL 和 IBIL 水平分别为（13.9±7.6）、（6.4±4.3）和（7.5±3.4）μmol / L，明显高于对照组的（6.2±2.0）、（3.2±1.2）和（3.0±1.4）μmol / L（P ＜0.05）。血清白蛋白含量与各项胆红素指标间均未见统计相关性（ P ＞0.05）。结论职业接触二氯甲烷可能导致 TP、ALB、GloB、CHE 降低，胆红素指标升高；可能与机体肝脏的合成功能和胆红素代谢能力下降以及机体红细胞破坏增加有关。
목적：탐색이록갑완폭로대가구제조공인간공능적영향。방법선택가구제조기업상효공인화령일기업의상강공인，안년령、성별진행1∶1배대，납입폭로조화대조조각22명공인。측정폭로공인공작장소이록갑완농도，검측병비교량조공인혈청총단백（TP）、백단백（ALB）、구단백（GloB）、곡병전안매（ALT）、곡초전안매（AST）、선감탈안매（ADA）、담감지매（CHE）、총담홍소（TBIL）、직접담홍소（DBIL）화간접담홍소（IBIL）등간공능지표。결과폭로조공작장소이록갑완농도위1300～7760 mg/ m3，폭로조공인혈청 TP、ALB화 GloB 함량분별위（73.7±3.6）、（47.5±2.3）화（26.2±2.8）g/ L，균저우대조조적（79.2±4.2）、（49.9±3.2）화（29.2±3.3）g/ L（P ＜0.05）；폭로조공인혈청 CHE、ADA、AST 화 ALT 활력수평분별위（7477.8±1240.8）、（7.3±1.7）、（21.6±5.6）화（13.0±5.6）U/ L，균저우대조조적（9523.9±2010.3）、（9.1±2.0）、（26.6±9.4）화（29.0±16.7） U/ L（ P ＜0.05）；폭로조공인혈청 TBIL、DBIL 화 IBIL 수평분별위（13.9±7.6）、（6.4±4.3）화（7.5±3.4）μmol / L，명현고우대조조적（6.2±2.0）、（3.2±1.2）화（3.0±1.4）μmol / L（P ＜0.05）。혈청백단백함량여각항담홍소지표간균미견통계상관성（ P ＞0.05）。결론직업접촉이록갑완가능도치 TP、ALB、GloB、CHE 강저，담홍소지표승고；가능여궤체간장적합성공능화담홍소대사능력하강이급궤체홍세포파배증가유관。
Objective To explore the effects of dichloromethane(DCM)exposure on serum biochemical indexes among furniture manufacturing workers. Methods A total of 65 workers who engaged in adhesive operations in furniture manufactory and 56 workers who would be recruited into another factory as new employees were investigated. Twenty two pairs of workers were selected as occupationally exposure group and control group,respectively. The concentration of DCM in workplace of adhesive operations in furniture manufactory was determined. Serum levels of TP,ALB,GloB,A/ G, ALT,AST,GGT,AFU,GPDA,ADA,ALP,CHE,CHOL,TG,TBA,TBIL,DBIL and IBIL were tested by automatic biochemical analyzer in all groups. Results The mean levels of serum TP,ALB,GloB in exposure group( the concentrations of DCM in workplace were 1 300 - 7 760 mg/ m3 )were 73. 7 ± 3. 6,47. 5 ± 2. 3 and 26. 2 ± 2. 8 g/ L,which were significantly lower than that of control group(P < 0. 05). Compared to the control group,the mean levels of CHE, ADA,AST and ALT activity in exposure group(7 477. 8 ± 1 240. 8,7. 3 ± 1. 7,21. 6 ± 5. 6 and 13. 0 ± 5. 6 U/ L)were significantly lower(P < 0. 05). The mean levels of TBIL,DBIL and IBIL were 13. 9 ± 7. 6,6. 4 ± 4. 3 and 7. 5 ± 3. 4μmol/ L,respectively,which were significantly higher than that of control group(P < 0. 05). No significant difference in the mean levels of the other biochemical indexes in serum was observed between exposure and control group. However,no correlation was found between the levels of ALB and TBIL,ALB and DBIL,or ALB and IBIL. Conclusion Occupational exposure to DCM is associated with the decrease of TP,ALB,GloB and CHE levels in serum. Meanwhile,DCM occupational exposure is correlated with the increase of TBIL,DBIL and IBIL levels in serum. Our data suggest that occupational exposure to DCM may be related to inhibition of synthetic function in live,damage of blood cells and declined metabolism of bilirubin.