CAJ | 학술논문

目的：探讨饮用绿茶对血管性认知功能障碍（ VCI）患者体内氧化应激反应的影响。方法将入选的VCI患者依据饮用绿茶的习惯分为两组，即饮茶者组和非饮茶者组，采用简易精神状态检查表（MMSE）和蒙特利尔认识评估量表（MoCA）检测认知功能，取肘静脉血测定丙二醛（MDA）、4-羟基壬烯醛（4-HNE）及8-羟化脱氧鸟苷（8-OHdG ）的含量。结果所入选的 VCI 患者中，饮茶者组的 MMSE 评分（26．62±0．41）稍高于非饮茶者组（26．17±0．38），统计学分析显示两组差异无统计学意义（P＞0．05）。但饮茶者组的MoCA评分（23．29±0．61）高于非饮用绿茶者组（21．12±0．50），差异具有统计学意义（P＜0．05）。饮茶者外周血的 MDA 含量（2．345±0．3697）低于非饮茶者（4．437±0．3710），以及饮茶者外周血4-HNE 含量（4．919±0．9378）低于非饮茶者（8．660±0．7883），差异均具有统计学意义（P＜0．01），而饮茶者8-OHdG浓度（1845±121．5）虽低于非饮茶者（2322±203．4），但差异无统计学意义（P＞0．05）。结论常饮绿茶可能具有抑制VCI患者的氧化应激反应，改善认知功能的作用，但绿茶对抑制氧化性DNA损伤的作用较弱。
목적：탐토음용록다대혈관성인지공능장애（ VCI）환자체내양화응격반응적영향。방법장입선적VCI환자의거음용록다적습관분위량조，즉음다자조화비음다자조，채용간역정신상태검사표（MMSE）화몽특리이인식평고량표（MoCA）검측인지공능，취주정맥혈측정병이철（MDA）、4-간기임희철（4-HNE）급8-간화탈양조감（8-OHdG ）적함량。결과소입선적 VCI 환자중，음다자조적 MMSE 평분（26．62±0．41）초고우비음다자조（26．17±0．38），통계학분석현시량조차이무통계학의의（P＞0．05）。단음다자조적MoCA평분（23．29±0．61）고우비음용록다자조（21．12±0．50），차이구유통계학의의（P＜0．05）。음다자외주혈적 MDA 함량（2．345±0．3697）저우비음다자（4．437±0．3710），이급음다자외주혈4-HNE 함량（4．919±0．9378）저우비음다자（8．660±0．7883），차이균구유통계학의의（P＜0．01），이음다자8-OHdG농도（1845±121．5）수저우비음다자（2322±203．4），단차이무통계학의의（P＞0．05）。결론상음록다가능구유억제VCI환자적양화응격반응，개선인지공능적작용，단록다대억제양화성DNA손상적작용교약。
Objective To explore the influence of drinking green tea on oxidative stress response of patients with vascular cognitive impairment( VCI) .Methods The involved patients with vascular cognitive impairment were divided into two groups according to the habit of drinking green tea:drinking green tea group and non-drinking green tea group.The cognitive function was measured by Mini Mental State Examination ( MMSE)and Montreal Cognitive Assessment ( MoCA ) .The oxidative stress response was evaluated by the level of malondialdehyde ( MDA ) , 4-hydroxynonenal(4-HNE) and 8-hydroxy-2ˊ-deoxyguanosine (8 -OHdG) in elbow venous blood.Results Of all participants with VCI, the scores of MMSE between drinking green tea group (26.62±0.41) and non-drinking green tea group (26.17±0.38) had no significant difference ( P>0.05),while the scores of MoCA in drinking green tea group (23.29 ±0.61) higher than that in non-drinking green tea group ( 21.12 ±0.50) and they had significant difference (P<0.05).The levels of MDA in peripheral blood with drinking green tea habit (23.45±0.3697) lowered than those with non-drinking green tea habit(4.437±0.3710), and 4-HNE in peripheral blood with drinking green tea habit(4.919±0.9378) lowered than those with non -drinking green tea habit (8.660±0.7883),there were significant differences(P<0.01).The plasma 8-OHdG concentration in patient with drinking green tea habit (1845±121.5) was lower than that with non-drinking green tea habit(2322±203.4), but there were no significant difference(P>0.05). Conclusion To drinking green tea frequently could inhibit the oxidative stress response and enhance the cognitive function in patients with VCI.The inhibitory effect of green tea to oxidative DNA injury had undefined.