CAJ | 학술논문

目的：探讨CK19、Galectin-3及CD56在良恶性卵巢甲状腺肿鉴别诊断中的应用价值。方法：采用免疫组化法检测6例卵巢甲状腺癌和10例卵巢甲状腺肿组织中CK19、Galectin-3及CD56蛋白表达情况。结果：卵巢甲状腺癌组织中CK19、Galectin-3蛋白的表达高于卵巢甲状腺肿组织（t＝4．807，3．835，P均＜0．05），CD56蛋白的表达低于卵巢甲状腺肿组织（t＝3．105，P均＜0．05）。分别利用CK19、Galectin-3及CD56蛋白表达水平绘制ROC曲线，曲线下面积（AUC）分别为0．983、0．933和0．867；以其中1个指标恶性即判定为恶性，则3者联合检测对良恶性卵巢甲状腺肿鉴别诊断的灵敏度可达100％。结论：CK19、Galectin-3及CD56对卵巢甲状腺肿良恶性的鉴别有很好的应用价值。
목적：탐토CK19、Galectin-3급CD56재량악성란소갑상선종감별진단중적응용개치。방법：채용면역조화법검측6례란소갑상선암화10례란소갑상선종조직중CK19、Galectin-3급CD56단백표체정황。결과：란소갑상선암조직중CK19、Galectin-3단백적표체고우란소갑상선종조직（t＝4．807，3．835，P균＜0．05），CD56단백적표체저우란소갑상선종조직（t＝3．105，P균＜0．05）。분별이용CK19、Galectin-3급CD56단백표체수평회제ROC곡선，곡선하면적（AUC）분별위0．983、0．933화0．867；이기중1개지표악성즉판정위악성，칙3자연합검측대량악성란소갑상선종감별진단적령민도가체100％。결론：CK19、Galectin-3급CD56대란소갑상선종량악성적감별유흔호적응용개치。
Aim:To explore the value of CK19,Galectin-3 and CD56 in differential diagnosis about benign and malig-nant struma ovarii.Methods:The expressions of CK19,Galectin-3,and CD56 protein in 6 cases of thyroid carcinoma of ovary and 10 cases of ovarian goiter tissue were detected using immunohistochemical staining technique .Results: Compared with those of the ovarian goiter tissue , the expressions of CK19 and Galectin-3 were higher and CD56 protein expression was lower in thyroid carcinoma of ovary tissue (t=4.807,3.835,3.105,P<0.05).The AUC of ROC about CK19,Galectin-3,and CD56 protein was 0.983,0.933 and 0.867,respectively, and sensitivity of the joint detection with the 3 proteins was 100%.Con-clusion:CK19,Galectin-3 and CD56 may be used as diagnostic indicators of benign and malignant struma ovarii .