CAJ | 학술논문

神经分泌素（SN）是分泌粒蛋白 II（SgII）前体最保守的序列，由33～34个氨基酸组成．在硬骨鱼类的世系中，可能发生特定的基因组复制事件产生 SN 的两个旁系同源基因：SNa 和 SNb．在所有已知 SN 肽的中央核心都包含“YTPQ-X-LA-X7-EL”这10个相同的氨基酸．SN 免疫反应（SN-ir）在哺乳动物主要的垂体细胞类型中发现．其内分泌功能最显著的例子是刺激金鱼垂体和小鼠 LβT2促性腺激素细胞中促黄体生成素的释放，表明SN 在生殖调控中有重要作用．研究表明，SN 受体有可能是一个 G 蛋白偶联受体．文章对 SN 的起源、结构、调控垂体激素及其作用机制等方面的最新研究进展予以综述，并展望了 SN 今后的发展前景．
신경분비소（SN）시분비립단백 II（SgII）전체최보수적서렬，유33～34개안기산조성．재경골어류적세계중，가능발생특정적기인조복제사건산생 SN 적량개방계동원기인：SNa 화 SNb．재소유이지 SN 태적중앙핵심도포함“YTPQ-X-LA-X7-EL”저10개상동적안기산．SN 면역반응（SN-ir）재포유동물주요적수체세포류형중발현．기내분비공능최현저적례자시자격금어수체화소서 LβT2촉성선격소세포중촉황체생성소적석방，표명SN 재생식조공중유중요작용．연구표명，SN 수체유가능시일개 G 단백우련수체．문장대 SN 적기원、결구、조공수체격소급기작용궤제등방면적최신연구진전여이종술，병전망료 SN 금후적발전전경．
Secretoneurin (SN)is derived from the most conservative sequence of the precursor secretogranin II (SgII),consists of 33 ~34 amino acids.In the teleost lineage,the specific genome duplication events that may occur to produce both paralogs of SN:SNa and SNb.In all known SN peptides,it contains 10 same amino acid with signature YTPQ-X-LA-X7-EL of the central core.Secretoneurin immunoreactivity (SN-ir)is found in the primarily mammalian pituitary cell types.The most notable example of the endocrine function of SN is the stimu-lation on luteinizing hormone release from goldfish pituitary cells and mouse LβT2 gonadotroph cells,which sug-gests that SN plays an important role in the regulation of reproduction.Studies have shown that SN receptor may be a G protein-coupled receptors.In this paper,we summarize the origin and structure of Secretoneurin,regula-ting the hormone of pituitary and mechanism of action for SN in the recent research progress.The research of SN trends for the future development prospects are proposed.