磁共振成像
磁共振成像
자공진성상
Chinese Journal of Magnetic Resonance Imaging
2015年
11期
848-854
,共7页
张冬%吴婷%史长征%罗良平
張鼕%吳婷%史長徵%囉良平
장동%오정%사장정%라량평
前列腺%磁共振成像%年龄因素
前列腺%磁共振成像%年齡因素
전렬선%자공진성상%년령인소
Prostate%Magnetic resonance imaging%Age factors
目的:探讨体素内不相干运动扩散加权成像(IVIM-DWI)各相关参数在正常前列腺组织中的可重现性,并分析其随年龄的变化趋势。材料与方法将66名符合纳入标准的各年龄段健康志愿者分成三组(A组,15~30岁,13名;B组,31~50岁,25名;C组,≥51岁,28名),在3.0 T磁场强度下对志愿者行IVIM-DWI扫描,休息30 min后行第二次IVIM-DWI扫描(b值0、25、50、75、100、150、200、400、600、800、1000、1200、1500、2000、3000 s/mm2),应用双指数模型对信号衰减进行分析得出slow ADC值,fast ADC值及f值。采用配对样本t检验研究前后两次扫描之间的差异,探讨各参数的可重现性;采用方差分析(ANOVA)及LSD法对各参数在不同年龄段正常前列腺组织中的差异进行比较,分析其随年龄的变化趋势。结果 A组健康志愿者前列腺中央腺fast ADC值两次测量数据差异有统计学意义(P=0.022),其余各参数两次测量数据差异没有统计学意义;slow ADC值外周带A、B组及A、C组间差异有统计学意义,B、C组间差异无统计学意义,中央腺A、C组及B、C组间差异有统计学意义,A、B组间差异无统计学意义;fast ADC值外周带及中央腺各组两两间均无显著性差异;f值外周带各组两两间均有显著性差异,中央腺A、C组及B、C组间差异有统计学意义,A、B组间差异无统计学意义;前列腺外周带及中央腺slow ADC值、f值总体上随年龄段升高呈上升趋势。结论不同年龄段正常前列腺组织的IVIM-DWI各相关参数总体上具有良好的可重现性;应用影像学手段,通过对IVIM-DWI相关参数的分析,可以定量的反映前列腺随年龄升高而发生的各种细胞水平的变化,为前列腺疾病的诊断及定量分析提供可靠的依据。
目的:探討體素內不相榦運動擴散加權成像(IVIM-DWI)各相關參數在正常前列腺組織中的可重現性,併分析其隨年齡的變化趨勢。材料與方法將66名符閤納入標準的各年齡段健康誌願者分成三組(A組,15~30歲,13名;B組,31~50歲,25名;C組,≥51歲,28名),在3.0 T磁場彊度下對誌願者行IVIM-DWI掃描,休息30 min後行第二次IVIM-DWI掃描(b值0、25、50、75、100、150、200、400、600、800、1000、1200、1500、2000、3000 s/mm2),應用雙指數模型對信號衰減進行分析得齣slow ADC值,fast ADC值及f值。採用配對樣本t檢驗研究前後兩次掃描之間的差異,探討各參數的可重現性;採用方差分析(ANOVA)及LSD法對各參數在不同年齡段正常前列腺組織中的差異進行比較,分析其隨年齡的變化趨勢。結果 A組健康誌願者前列腺中央腺fast ADC值兩次測量數據差異有統計學意義(P=0.022),其餘各參數兩次測量數據差異沒有統計學意義;slow ADC值外週帶A、B組及A、C組間差異有統計學意義,B、C組間差異無統計學意義,中央腺A、C組及B、C組間差異有統計學意義,A、B組間差異無統計學意義;fast ADC值外週帶及中央腺各組兩兩間均無顯著性差異;f值外週帶各組兩兩間均有顯著性差異,中央腺A、C組及B、C組間差異有統計學意義,A、B組間差異無統計學意義;前列腺外週帶及中央腺slow ADC值、f值總體上隨年齡段升高呈上升趨勢。結論不同年齡段正常前列腺組織的IVIM-DWI各相關參數總體上具有良好的可重現性;應用影像學手段,通過對IVIM-DWI相關參數的分析,可以定量的反映前列腺隨年齡升高而髮生的各種細胞水平的變化,為前列腺疾病的診斷及定量分析提供可靠的依據。
목적:탐토체소내불상간운동확산가권성상(IVIM-DWI)각상관삼수재정상전렬선조직중적가중현성,병분석기수년령적변화추세。재료여방법장66명부합납입표준적각년령단건강지원자분성삼조(A조,15~30세,13명;B조,31~50세,25명;C조,≥51세,28명),재3.0 T자장강도하대지원자행IVIM-DWI소묘,휴식30 min후행제이차IVIM-DWI소묘(b치0、25、50、75、100、150、200、400、600、800、1000、1200、1500、2000、3000 s/mm2),응용쌍지수모형대신호쇠감진행분석득출slow ADC치,fast ADC치급f치。채용배대양본t검험연구전후량차소묘지간적차이,탐토각삼수적가중현성;채용방차분석(ANOVA)급LSD법대각삼수재불동년령단정상전렬선조직중적차이진행비교,분석기수년령적변화추세。결과 A조건강지원자전렬선중앙선fast ADC치량차측량수거차이유통계학의의(P=0.022),기여각삼수량차측량수거차이몰유통계학의의;slow ADC치외주대A、B조급A、C조간차이유통계학의의,B、C조간차이무통계학의의,중앙선A、C조급B、C조간차이유통계학의의,A、B조간차이무통계학의의;fast ADC치외주대급중앙선각조량량간균무현저성차이;f치외주대각조량량간균유현저성차이,중앙선A、C조급B、C조간차이유통계학의의,A、B조간차이무통계학의의;전렬선외주대급중앙선slow ADC치、f치총체상수년령단승고정상승추세。결론불동년령단정상전렬선조직적IVIM-DWI각상관삼수총체상구유량호적가중현성;응용영상학수단,통과대IVIM-DWI상관삼수적분석,가이정량적반영전렬선수년령승고이발생적각충세포수평적변화,위전렬선질병적진단급정량분석제공가고적의거。
Objective:To investigate the reproducibility of the intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) derived parameters, and analyze the change of the IVIM-DWI derived parameters of normal prostate in different age groups. Materials and Methods:Sixty-six volunteers conformed to the standards were divided into three groups (group A, 15—30 years, 13. Group B, 31—50 years, 25. Group C,≥51 years, 28) and underwent the scanning of IVIM-DWI with 15 b-factors from 0 to 3000 (0, 25, 50, 75, 100, 150, 200, 400, 600, 800, 1000, 1200, 1500, 2000, 3000 s/mm2) twice with an interval of 30 minutes using 3.0 T MRI device, the biexponential ifts were applied to ifgure out the slow ADC, fast ADC and f values. The reproducibility of every parameters were investigated by the paired t-test. The differences of every parameters in normal prostate between the three age groups were assessed using one-way analysis of variance (ANOVA) and the least significant difference (LSD) t-test. Results: Slow ADC, fast ADC and f values showed good reproducibility in both peripheral zone (PZ) and central gland (CG) of three age groups, except fast ADC in CG of group A (P=0.022). The slow ADC and f values of the prostate peripheral zone and central gland had the upward tendency with age increasing. Slow ADC showed signiifcant difference between group A and B, group A and C, while had no signiifcant difference between group B and C in PZ, and slow ADC showed signiifcant difference between group A and C, group B and C, while had no signiifcant difference between group A and B in CG. Fast ADC in both PZ and CG between three age groups had no signiifcant different. F value show signiifcant difference between three age groups in PZ, while in CG f value show signiifcant difference between group A and C, group B and C, while had no signiifcant difference between group A and B. Conclusions:In general, a good reproducibility of IVIM-DWI derived parameters in normal prostate of three age groups was observed. IVIM-DWI technology relfected the age-related change of prostate tissues in the celluar level, and the derived parameters could set a reliable reference to the quantitative analysis of prostate diseases.