CAJ | 학술논문

目的：探讨MRI测量T2弛豫时间定量评估颈椎间盘退变及年龄、节段相关变化的价值。材料与方法40名健康受试者进行了颈椎常规MRI和T2-mapping检查。对椎间盘进行Pfirrmann分级，并测量髓核的T2弛豫时间值(T2值)。结果颈椎间盘髓核T2值与Pfirrmann分级负相关(r=－0.64，P<0.01)。不同Pfirrmann分级椎间盘的髓核T2值差异有统计学意义(F=48.2，P<0.01)，各级间两两比较T2值差异均有统计学意义(P<0.05)。T2值鉴别Ⅰ级与Ⅱ级、Ⅱ级与Ⅲ级、Ⅲ级与Ⅳ级椎间盘的ROC曲线下面积分别为0.79、0.81和0.78(P<0.05)。18～30岁组髓核T2值大于31～40岁组(P<0.05)。18～30岁组不同解剖节段的髓核T2值差异有统计学意义(P<0.05)；而31～40岁组不同解剖节段的髓核T2值差异无统计学意义(P>0.05)。结论 MRI测量T2弛豫时间值能量化评估颈椎间盘退变及其年龄、解剖节段相关变化，具有一定的临床价值，应作为评估颈椎间盘退变的补充序列。
목적：탐토MRI측량T2이예시간정량평고경추간반퇴변급년령、절단상관변화적개치。재료여방법40명건강수시자진행료경추상규MRI화T2-mapping검사。대추간반진행Pfirrmann분급，병측량수핵적T2이예시간치(T2치)。결과경추간반수핵T2치여Pfirrmann분급부상관(r=－0.64，P<0.01)。불동Pfirrmann분급추간반적수핵T2치차이유통계학의의(F=48.2，P<0.01)，각급간량량비교T2치차이균유통계학의의(P<0.05)。T2치감별Ⅰ급여Ⅱ급、Ⅱ급여Ⅲ급、Ⅲ급여Ⅳ급추간반적ROC곡선하면적분별위0.79、0.81화0.78(P<0.05)。18～30세조수핵T2치대우31～40세조(P<0.05)。18～30세조불동해부절단적수핵T2치차이유통계학의의(P<0.05)；이31～40세조불동해부절단적수핵T2치차이무통계학의의(P>0.05)。결론 MRI측량T2이예시간치능양화평고경추간반퇴변급기년령、해부절단상관변화，구유일정적림상개치，응작위평고경추간반퇴변적보충서렬。
Abrtract Objective: To explore the value of T2 relaxation time (T2 value) measurement in detecting cervical intervertebral disc degeneration, and assessing age and disc level related intervertebral disc changes. Materials and Methods: Forty asymptomatic adult volunteers were examined at 1.5 T MR by T2-weighted sagittal imaging and T2-mapping. For all participants, Pfirrmann grading system and T2 value were used to evaluate the degenerative degree of the disks. Results:Signiifcant negative correlation were observed between Pifrrmann grades and T2 values of cervical intervertebral disc (r=-0.64, P<0.01). ANOVA (analysis of variance) among different Pfirrmann grades showed significant differences in T2 values (F=48.2,P<0.01), and signiifcant differences were seen between any 2 grades (P<0.05). The area under ROC curve of T2 value were 0.79, 0.81 and 0.78 (P<0.05) separately when gradeⅠvs.Ⅱ,Ⅱvs.Ⅲ, andⅢvs.Ⅳ. T2 values of 18—30 age group were higher than 31—40 age group participants (P<0.05). Signiifcant differences among different disc level were observed in 18—30 age group (P<0.05). However, in 31—40 age group, no significant differences of disc level were demonstrated (P>0.05). Conclusions:T2 relaxation time measurement is a quantitative-parameter for assessing cervical intervertebral disc degeneration and age and disc level related disc changes, and shall be used as a complementary sequence in detecting cervical disc degeneration for its certain clinical value.