CAJ | 학술논문

目的：观察尾加压素Ⅱ在自发性高血压大鼠模型血浆中第8周、12周、18周和24周的动态变化；方法：随机抽取生后6周雄性自发性高血压大鼠40只为实验组，6周正常雄性 Waster 大鼠40只为对照组，分别在第8周、12周、18周和24周，随机抽取实验组和对照组各10只大鼠迅速于麻醉后心脏取血，分别测定各时点血浆 UⅡ浓度。结果：实验组和对照组 UⅡ对比有显著差异性（P ＜0.01）。结论：实验组大鼠血浆 UⅡ均显著升高，UⅡ在自发性高血压的发生发展过程中发挥非常的重要作用。
목적：관찰미가압소Ⅱ재자발성고혈압대서모형혈장중제8주、12주、18주화24주적동태변화；방법：수궤추취생후6주웅성자발성고혈압대서40지위실험조，6주정상웅성 Waster 대서40지위대조조，분별재제8주、12주、18주화24주，수궤추취실험조화대조조각10지대서신속우마취후심장취혈，분별측정각시점혈장 UⅡ농도。결과：실험조화대조조 UⅡ대비유현저차이성（P ＜0.01）。결론：실험조대서혈장 UⅡ균현저승고，UⅡ재자발성고혈압적발생발전과정중발휘비상적중요작용。
Objective:To investigate the dynamic change of urotensinⅡ in spontaneously hypertensive rats’blood plasma at the 8th week,12th week,18th week,24th week.Methods:A total of 40 male rats with spontaneously hypertensive at 6th week were random selected as the experimental group,and 40 normal male rats were recruited as control group.At the 8th week,12th week,18th week,24th week,10 rats in each groups were randomly sacrifice and the heart blood was harvested after rapid anesthesia.U Ⅱ concentra-tion was determined at each stage.Results:There are significant differences between experimental group and control group (P <0.01).Conclusion.UⅡ plays an important role in occurrence,development and path physiological process of spontaneous hypertension disease.