CAJ | 학술논문

目的：分析血管周围间隙(Virchow-Robin spaces，VRS)MRI影像表现与阿尔茨海默病(Alzheimer’s disease，AD)的相关性。材料与方法选取AD患者(阿尔茨海默病组)70例和健康体检者(对照组)62例，进行标准头颅MRI检查，计数中脑、基底节区、岛叶深部白质、半卵圆中心VRS的数目并测量其直径，对所得数据进行分析。结果 AD组颅脑MRI上可观察到VRS，以基底节区最为常见。AD组VRS检出率(49.1%，34/70)高于对照组(24.2%，15/62)，差异具有统计学意义(P<0.05)。AD组VRS的平均数目[(4.1±2.2)个/例]多于对照组[(2.4±1.9)个/例]，差异具有统计学意义(P<0.05)。AD组VRS的平均直径[(2.8±1.2) mm]大于对照组[(1.8±0.5) mm](P<0.05)，差异具有统计学意义。多元线性回归分析显示对照组中VRS的数目、直径均与年龄呈正相关(r1=0.802，r2=0.902，均P<0.05)。结论 AD组VRS的MRI影像表现具有一定的特征性，应引起临床的重视。
목적：분석혈관주위간극(Virchow-Robin spaces，VRS)MRI영상표현여아이자해묵병(Alzheimer’s disease，AD)적상관성。재료여방법선취AD환자(아이자해묵병조)70례화건강체검자(대조조)62례，진행표준두로MRI검사，계수중뇌、기저절구、도협심부백질、반란원중심VRS적수목병측량기직경，대소득수거진행분석。결과 AD조로뇌MRI상가관찰도VRS，이기저절구최위상견。AD조VRS검출솔(49.1%，34/70)고우대조조(24.2%，15/62)，차이구유통계학의의(P<0.05)。AD조VRS적평균수목[(4.1±2.2)개/례]다우대조조[(2.4±1.9)개/례]，차이구유통계학의의(P<0.05)。AD조VRS적평균직경[(2.8±1.2) mm]대우대조조[(1.8±0.5) mm](P<0.05)，차이구유통계학의의。다원선성회귀분석현시대조조중VRS적수목、직경균여년령정정상관(r1=0.802，r2=0.902，균P<0.05)。결론 AD조VRS적MRI영상표현구유일정적특정성，응인기림상적중시。
Objective:To study the correlation between Magnetic Resonance Imaging of Virchow-Robin spaces (VRS) and Alzheimer’s disease (AD). Materials and Methods:Seventy AD patients (AD group) and sixty-two normal controls (control group) were detected by brain MRI, and their VRS in the midbrain, basal ganglia, deep insular white matter and centrum semiovale were numbered and measured. The results were compared between the two groups. Results: VRS were observed in multiple brain regions of AD groups, typically in basal ganglia. The discovery rate of VRS in AD group (49.1%, 34/70) was higher than that in control group (24.2%, 15/62), the difference is statistically significant (P<0.05).The number of VRS in AD group [(4.1±2.2)/case] was more than that in control group [(2.4±1.9)/case], the difference is statistically signiifcant (P<0.05).The diameter of VRS in AD group [(2.8±1.2) mm] was larger than that in control group [(1.8±0.5) mm], the difference is statistically significant (P<0.05). Linear regression analysis showed the number, diameter of VRS in control group were both positive correlated with the age (r1=0.802, r2=0.902, all P<0.05). Conclusions:VRS in AD has its own characteristics, should cause the attention of clinical.