CAJ | 학술논문

线粒体单链DNA结合蛋白（mtSSBP1）是定位于线粒体基质和拟核的同源四聚体，在线粒体DNA的复制、转录以及损伤后修复等一系列生物学行为中发挥着重要作用。当 mtSSBP1表达失调时，mtDNA发生基因突变，尤其是处于恶劣的环境条件下，如高氧化应激、水解脱氨基反应、烷基化作用，DNA损伤将大量积累，最终导致多种相关疾病的发生、发展。目前关于mtSSBP1的分子机制及其与疾病相关分子通路的研究正处于探索阶段，该文就近年来的研究进展予以综述。
선립체단련DNA결합단백（mtSSBP1）시정위우선립체기질화의핵적동원사취체，재선립체DNA적복제、전록이급손상후수복등일계렬생물학행위중발휘착중요작용。당 mtSSBP1표체실조시，mtDNA발생기인돌변，우기시처우악렬적배경조건하，여고양화응격、수해탈안기반응、완기화작용，DNA손상장대량적루，최종도치다충상관질병적발생、발전。목전관우mtSSBP1적분자궤제급기여질병상관분자통로적연구정처우탐색계단，해문취근년래적연구진전여이종술。
mtSSBP1,the mitochondria single-strand DNA protein,located on the mitochondrial matrix and proposed nuclear with the structure of homo-tetramer,plays essential roles in a series of biological behav-ior,including the replication,transcription,and the repair after injury of mtDNA.The expression disorder of mtSSBP1 leads to the gene mutation of mtDNA,especially under the harsh environment and conditions,such as oxidation,hydrolytic deamination,alkylation adducts,the accumulation of high levels of mtDNA damage will lead to the generation and development of various related diseases.The study of mtSSBP1 molecular mechanism and diseases related pathways is at the exploration stage at present,and here is to make a review of the recent research advances of mtSSBP1.