现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
Modern Journal of Integrated Traditional Chinese and Western Medicine
2015年
33期
3665-3667,3670
,共4页
李鹏%张庆九%马法%刘岚%李旭蕊%李晓燕
李鵬%張慶九%馬法%劉嵐%李旭蕊%李曉燕
리붕%장경구%마법%류람%리욱예%리효연
侵袭性垂体瘤%非侵袭性垂体瘤%PI3K%AKT%PTEN%免疫组织化学
侵襲性垂體瘤%非侵襲性垂體瘤%PI3K%AKT%PTEN%免疫組織化學
침습성수체류%비침습성수체류%PI3K%AKT%PTEN%면역조직화학
invasive pituitary adenomas%non-invasive pituitary adenomas%PI3K%AKT%PTEN%immunohistochemistry
目的：探讨PI3K、AKT、PTEN在侵袭性垂体瘤和非侵袭性垂体瘤中的表达情况以及三者在侵袭性垂体瘤中的相关性。方法将58例手术切除垂体瘤标本分为侵袭性组31例和非侵袭组27例。采用免疫组织化学技术检测2组标本中PI3K、AKT及PTEN的表达情况。结果 PI3K、AKT在侵袭组中的阳性表达率明显高于非侵袭组（P均＜0．05），PTEN在侵袭组中的阳性表达率明显低于非侵袭组（P＜0．05）。在侵袭组中，PTEN与PI3K、AKT表达呈显著负相关（r＝－0．39，P＝0．029；r＝－0．52，P＝0．002），而PI3K与AKT表达呈显著正相关（r＝0．45，P＝0．019）。结论侵袭性垂体瘤中PI3K、AKT阳性表达率较高，且与PTEN表达呈负相关，而PI3K与AKT表达呈正相关，为侵袭性垂体瘤提供了新的靶向治疗方向。
目的：探討PI3K、AKT、PTEN在侵襲性垂體瘤和非侵襲性垂體瘤中的錶達情況以及三者在侵襲性垂體瘤中的相關性。方法將58例手術切除垂體瘤標本分為侵襲性組31例和非侵襲組27例。採用免疫組織化學技術檢測2組標本中PI3K、AKT及PTEN的錶達情況。結果 PI3K、AKT在侵襲組中的暘性錶達率明顯高于非侵襲組（P均＜0．05），PTEN在侵襲組中的暘性錶達率明顯低于非侵襲組（P＜0．05）。在侵襲組中，PTEN與PI3K、AKT錶達呈顯著負相關（r＝－0．39，P＝0．029；r＝－0．52，P＝0．002），而PI3K與AKT錶達呈顯著正相關（r＝0．45，P＝0．019）。結論侵襲性垂體瘤中PI3K、AKT暘性錶達率較高，且與PTEN錶達呈負相關，而PI3K與AKT錶達呈正相關，為侵襲性垂體瘤提供瞭新的靶嚮治療方嚮。
목적：탐토PI3K、AKT、PTEN재침습성수체류화비침습성수체류중적표체정황이급삼자재침습성수체류중적상관성。방법장58례수술절제수체류표본분위침습성조31례화비침습조27례。채용면역조직화학기술검측2조표본중PI3K、AKT급PTEN적표체정황。결과 PI3K、AKT재침습조중적양성표체솔명현고우비침습조（P균＜0．05），PTEN재침습조중적양성표체솔명현저우비침습조（P＜0．05）。재침습조중，PTEN여PI3K、AKT표체정현저부상관（r＝－0．39，P＝0．029；r＝－0．52，P＝0．002），이PI3K여AKT표체정현저정상관（r＝0．45，P＝0．019）。결론침습성수체류중PI3K、AKT양성표체솔교고，차여PTEN표체정부상관，이PI3K여AKT표체정정상관，위침습성수체류제공료신적파향치료방향。
Objective It is to investigate the expreession and correlation of PI 3K, AKT and PTEN in invasive pituitary ad-enomas and non-invasive pituitary adenomas .Methods 58 cases of pituitary adenomas specimen of surgical resection were di-vided into invasive pituitary adenomas group with 31 cases and non-invasive pituitary adenomas group with 27 cases.The ex-pression of PI3K, AKT and PTEN in invasive pituitary adenomas group and non-invasive pituitary adenomas group were detec-ted by immunohistochemistry method .Results The positive rate of the expression of PI 3K, AKT in invasive pituitary adenomas group was respectively higher than that in non-invasive pituitary adenomas group ( all P<0.05 ) .The positive rate of the ex-preession of PTEN in invasive pituitary adenomas group was lower than that in non -invasive pituitary adenomas group ( P<0.05 ) .Negative correlation was founded between PTEN and PI 3K, AKT in invasiveness pituitary adenomas ( r=-0.39, P=0.029;r=-0.52, P=0.002).But positive correlation was founded between PI 3K and AKT in invasiveness pituitary adeno-mas (r=0.45, P=0.019).Conclusion The expression levels of PI3K, AKT in invasive pituitary adenomas are higher , there are negative correlation between PTEN and PI 3K, AKT, and there were positive correlation between PI 3K and AKT. This provides a new direction for the treatment of invasive pituitary tumors .
