CAJ | 학술논문

目的：：探讨持续气道正压通气结合炎琥宁治疗先天性心脏病合并重症肺炎患儿的临床意义。方法：先天性心脏病合并重症肺炎患儿60例根据随机抽签原则分为治疗组与对照组各30例。对照组给予常规治疗措施及持续气道正压通气治疗,治疗组在对照组的基础上给予炎琥宁进行治疗。结果：治疗后1h 后经过观察,治疗组有效率显著高于对照组(P<0.05)。治疗前两组 PaO2和 SaO2对比无明显差异(P>0.05)；在治疗1h、6h 后,两组的 PaO2和SaO2显著升高(P<0.05),不过治疗组与对照组相比,PaO2和 SaO2升高更加明显,组间对比差异明显(P<0.05)。治疗前,两组血清 BNP 含量无显著差异,治疗后均明显上升(P<0.05),同时治疗组的血清BNP含量明显高于对照组(P<0.05)。结论：持续气道正压通气结合炎琥宁治疗先天性心脏病合并重症肺炎患儿可使患儿的动脉血氧饱和度和血氧分压迅速而显著提高,临床症状明显改善,其作用的发挥与降低血清BNP表达有关。
목적：：탐토지속기도정압통기결합염호저치료선천성심장병합병중증폐염환인적림상의의。방법：선천성심장병합병중증폐염환인60례근거수궤추첨원칙분위치료조여대조조각30례。대조조급여상규치료조시급지속기도정압통기치료,치료조재대조조적기출상급여염호저진행치료。결과：치료후1h 후경과관찰,치료조유효솔현저고우대조조(P<0.05)。치료전량조 PaO2화 SaO2대비무명현차이(P>0.05)；재치료1h、6h 후,량조적 PaO2화SaO2현저승고(P<0.05),불과치료조여대조조상비,PaO2화 SaO2승고경가명현,조간대비차이명현(P<0.05)。치료전,량조혈청 BNP 함량무현저차이,치료후균명현상승(P<0.05),동시치료조적혈청BNP함량명현고우대조조(P<0.05)。결론：지속기도정압통기결합염호저치료선천성심장병합병중증폐염환인가사환인적동맥혈양포화도화혈양분압신속이현저제고,림상증상명현개선,기작용적발휘여강저혈청BNP표체유관。
Obj ective:To investigate the clinical significance of continuous positive airway pressure combined Yanhuning injection for treating congenital heart disease with severe pneumonia in children.Methods:60 congenital heart disease with severe pneumonia children based on the principle of random draw were equally divided into the treatment group and the control group,the control group were received conventional treatment and continuous positive airway pres-sure,the treatment group were added the Yanhuning injection treatment.Results:After treatment 1h through observa-tion,the total efficiency of the treatment group and the control group were 90.0% and 60.0% respectively that compared were significantly difference (P<0.05).The PaO2 and SaO2 values compared between the two groups before treatment had no significant difference (P> 0.05);After treatment 1h,6h,the PaO2 and SaO2 values in the both groups were sig-nificantly higher (P<0.05),but the treatment group compared with the control group,PaO2 and SaO2 were increased more obvious than the control group(P<0.05).The serum BNP levels comparison between the two groups were not sta-tistically significant before treatment,after treatment,the serum BNP levels were showed a clear upward trend (P<0. 05),while serum BNP levels in the treatment group were significantly higher (P<0.05 ).Conclusion:CPAP intermit-tent positive pressure ventilation combined Yanhuning inj ection in the treatment of severe pneumonia in children with con-genital heart disease can quickly improve arterial oxygen saturation and blood oxygen and improve clinical symptoms,it plays its role expressions may be related to lower serum BNP expression.