CAJ | 학술논문

目的：探讨新辅助化疗联合保乳术治疗女性Ⅱ、Ⅲ期乳腺癌的临床疗效。方法回顾性分析2009年1月至2010年12月解放军海军安庆医院收治的62例行新辅助化疗联合保乳术联合治疗的Ⅱ、Ⅲ期乳腺癌患者的临床资料，观察患者术后1年的临床疗效及随访情况。结果本组患者术后1年的临床效果评定结果显示，总有效率为77.4％（48／62），其中完全缓解20例（32.3％），部分缓解28例（45.2％），稳定14例（22.6％）。通过对术后2～3年的随访观察，局部复发2例，复发率为3.2％；本组的患者术后3年中均无死亡病例发生，生存状况良好。结论临床中对于女性Ⅱ、Ⅲ期乳腺癌患者行新辅助化疗联合保乳术治疗是可行的，能有效提高手术治疗效果，降低术后复发率。
목적：탐토신보조화료연합보유술치료녀성Ⅱ、Ⅲ기유선암적림상료효。방법회고성분석2009년1월지2010년12월해방군해군안경의원수치적62례행신보조화료연합보유술연합치료적Ⅱ、Ⅲ기유선암환자적림상자료，관찰환자술후1년적림상료효급수방정황。결과본조환자술후1년적림상효과평정결과현시，총유효솔위77.4％（48／62），기중완전완해20례（32.3％），부분완해28례（45.2％），은정14례（22.6％）。통과대술후2～3년적수방관찰，국부복발2례，복발솔위3.2％；본조적환자술후3년중균무사망병례발생，생존상황량호。결론림상중대우녀성Ⅱ、Ⅲ기유선암환자행신보조화료연합보유술치료시가행적，능유효제고수술치료효과，강저술후복발솔。
Objective To explore the clinical effects of neoadjuvant chemotherapy combined with breast-conserving surgery for the patients with stage Ⅱ and Ⅲ breast cancer.Methods Total of 62 patients with stage Ⅱ and Ⅲ breast cancer treated by neoadjuvant chemotherapy combined with breast-conserving surgery in PLA Navy Anqing Hospital from Jan.2009 to Dec.2010 were included in the study.Clinical data and follow-up of patients 1 year after surgery were observed.Results The total effective rate of this group of patients was 77.4% at 1 year after surgery.20 cases ( 32.3%) achieved complete response, 28 cases (45.2%) achieved partial response,and 14 cases (22.6%) achieved stable condition.After 2-3 years fol-low-up,local recurrence was found in 2 cases, the recurrence rate was 3.2%.There was no death in this group during 3 years follow up.Conclusion Neoadjuvant chemotherapy combined with breast-conserving surgery is feasible for the patients with stage Ⅱ and Ⅲ breast cancer,which can effectively improve surgical outcomes and reduce the recurrence.