郑州大学学报(医学版)
鄭州大學學報(醫學版)
정주대학학보(의학판)
Journal of Zhengzhou University (Medical Sciences)
2015年
6期
773-776
,共4页
孙逸杰%景戈翰%杨菁%何书平%仝冬晓%王丽雯%司沛茹%金璐%程晓丽
孫逸傑%景戈翰%楊菁%何書平%仝鼕曉%王麗雯%司沛茹%金璐%程曉麗
손일걸%경과한%양정%하서평%동동효%왕려문%사패여%금로%정효려
精神分裂症%多态性%mtDNA%TFAM
精神分裂癥%多態性%mtDNA%TFAM
정신분렬증%다태성%mtDNA%TFAM
schizophrenia%polymorphism%mtDNA%TFAM
目的:探讨线粒体转录因子A( TFAM)基因多态性与精神分裂症的关系。方法:采用PCR-RFLP及DNA序列分析技术分别对237例精神分裂症患者及246例健康对照TFAM基因rs10826178、rs4390300两多态位点进行检测及分析。结果:rs10826178与rs4390300位点等位基因与基因型频率分布在两组之间比较,差异无统计学意义(P均>0.05)。结论:TFAM基因rs4390300、rs10826178的基因型差异可能与精神分裂症的发病无关。
目的:探討線粒體轉錄因子A( TFAM)基因多態性與精神分裂癥的關繫。方法:採用PCR-RFLP及DNA序列分析技術分彆對237例精神分裂癥患者及246例健康對照TFAM基因rs10826178、rs4390300兩多態位點進行檢測及分析。結果:rs10826178與rs4390300位點等位基因與基因型頻率分佈在兩組之間比較,差異無統計學意義(P均>0.05)。結論:TFAM基因rs4390300、rs10826178的基因型差異可能與精神分裂癥的髮病無關。
목적:탐토선립체전록인자A( TFAM)기인다태성여정신분렬증적관계。방법:채용PCR-RFLP급DNA서렬분석기술분별대237례정신분렬증환자급246례건강대조TFAM기인rs10826178、rs4390300량다태위점진행검측급분석。결과:rs10826178여rs4390300위점등위기인여기인형빈솔분포재량조지간비교,차이무통계학의의(P균>0.05)。결론:TFAM기인rs4390300、rs10826178적기인형차이가능여정신분렬증적발병무관。
Aim:To research the relationship between mitochondrial transcription factor A ( TFAM) gene′s two poly-morphic loci and schizophrenia .Methods: The PCR-RFLP analysis and DNA sequencing technology were used to detect polymorphism of rs10826178 and rs4390300 in 237 cases of schizophrenia(patient group) and 246 healthy subjects(control group) .Results:The genotype frequencies and allele frequencies of TFAM gene rs 10826178 and rs4390300 in the two groups had no differences(P>0.05).Conclusion:TFAM gene rs10826178 and rs4390300 polymorphisms may not be as-sociated with schizophrenia .