CAJ | 학술논문

目的：通过对新发缺血性脑卒中患者进行登记、连续随访，评估卒中人群二级预防药物使用情况，及ABCD2‐1评分与卒中再发的相关性。方法新发缺血性脑卒中住院患者为研究对象，登记患者基本情况，危险因素、用药情况、AB‐CD2‐1评分，分别于发病后3、6、12月进行随访。结果脑卒中的易发年龄为45～60岁，且男性多于女性，分析其相关因素，如吸烟、高血压、高血脂、糖尿病等，发现男性缺血性脑卒中发病率高于女性，可能与男性吸烟比例高于女性相关（P＜0.01）。随访中调查二级预防药物（抗血小板聚集药物、他汀类药物）的使用能够有效地降低缺血性脑卒中的复发率（P＜0.05），但随着随访时间的延长，患者二级预防药物的使用率逐渐下降。对患者进行ABCD2‐1评分，显示ABCD2‐1评分与缺血性脑卒中复发率呈正相关（P＜0.05）。结论二级预防药物的使用能够有效降低缺血性脑卒中的复发率，ABCD2‐1评分可有效预测缺血性脑卒中再发风险，应对缺血性脑卒中患者建立完善的评估、长期连续性随访系统，提高二级预防药物使用率，降低缺血性脑卒中的再发风险。
목적：통과대신발결혈성뇌졸중환자진행등기、련속수방，평고졸중인군이급예방약물사용정황，급ABCD2‐1평분여졸중재발적상관성。방법신발결혈성뇌졸중주원환자위연구대상，등기환자기본정황，위험인소、용약정황、AB‐CD2‐1평분，분별우발병후3、6、12월진행수방。결과뇌졸중적역발년령위45～60세，차남성다우녀성，분석기상관인소，여흡연、고혈압、고혈지、당뇨병등，발현남성결혈성뇌졸중발병솔고우녀성，가능여남성흡연비례고우녀성상관（P＜0.01）。수방중조사이급예방약물（항혈소판취집약물、타정류약물）적사용능구유효지강저결혈성뇌졸중적복발솔（P＜0.05），단수착수방시간적연장，환자이급예방약물적사용솔축점하강。대환자진행ABCD2‐1평분，현시ABCD2‐1평분여결혈성뇌졸중복발솔정정상관（P＜0.05）。결론이급예방약물적사용능구유효강저결혈성뇌졸중적복발솔，ABCD2‐1평분가유효예측결혈성뇌졸중재발풍험，응대결혈성뇌졸중환자건립완선적평고、장기련속성수방계통，제고이급예방약물사용솔，강저결혈성뇌졸중적재발풍험。
Objective To investigate the service condition of the secondary prevention drugs in the patients with new cere‐bral ischemic stroke ,and evaluate the correlation of stroke recurrence rate with the usage of secondary prevention drugs or AB‐CD2‐1 criteria .Methods The basic situation ,risk factors ,drug use and ABCD2‐1 criteria of patients with new cerebral ische‐mic stroke were registered ,and the patients were followed up for the third ,sixth and twelfth month respectively after the onset of new cerebral ischemic stroke .Results The prone group of patients with ischemic stroke was 50‐60 years old ,and male pa‐tients were more than females ,this situation may be due to the proportion of male smokers higher than female smokers(P<0 . 01) .Secondary prevention drugs ,such as anti‐platelet aggregation drugs and statin drugs ,could reduce the recurrence rate of new cerebral ischemic stroke (P<0 .05) ,however ,the utilization rate of secondary prevention drugs gradually decreased .Giv‐ing an ABCD2‐1 score to each patient after healing ,the result indicated that the ABCD2‐1 score was positively correlated with the recurrence rate of ischemic stroke (P<0 .05) .Conclusion The usage of secondary prevention drugs could significantly re‐duce the recurrence rate of new cerebral ischemic stroke ,and ABCD2‐1 score could effectively forecast the risk of ischemic stroke recurrence .Therefore ,it is important to establish a long‐term follow‐up system to evaluate the recurrence rate of this disease and promote the usage of secondary prevention drugs ,to reduce the risk of recurrence of cerebral ischemic stroke .