CAJ | 학술논문

3-季碳螺环氧化吲哚作为一种重要的天然生物碱,其骨架一直是天然产物化学和药物化学领域里的研究热点.由于3-季碳螺环氧化吲哚骨架分子广泛具有抗氧化、抗焦虑、抗肿瘤等生物活性,近年来对其进行全合成和衍生化合成研究也持续升温.本文对3-季碳螺环氧化吲哚类化合物合成方法在近几年的研究进展进行了综述.
3-계탄라배양화신타작위일충중요적천연생물감,기골가일직시천연산물화학화약물화학영역리적연구열점.유우3-계탄라배양화신타골가분자엄범구유항양화、항초필、항종류등생물활성,근년래대기진행전합성화연생화합성연구야지속승온.본문대3-계탄라배양화신타류화합물합성방법재근궤년적연구진전진행료종술.
As an important functional group, the 3-quaternary carbon spirooxindole skeleton has always been a hot topic of ongoing interests, both in the natural products and in therapeutic agents. In recent years, tre-mendous interest has been devoted to the preparation of 3-quaternary carbon spirooxindoles due to their var-ied biological activities including antioxidant, antibacterial, and insecticidal behavior. The synthetic method of 3-quaternary carbon spirooxindoles is an powerful process in many real drug synthetic applications. This review summarizes the recent progress on this synthetic method of 3-quaternary carbon spirooxindoles.