CAJ | 학술논문

目的探讨乳腺纤维瘤病的临床病理特征及鉴别诊断要点. 方法回顾性分析5例乳腺纤维瘤病患者的临床资料并进行组织形态学、免疫组织化学研究, 对其临床表现、病理形态特点及鉴别诊断进行总结. 结果 5例均为女性,发病年龄24~75岁, 平均年龄53岁. 3例行乳腺病灶活检术, 2例行乳腺单纯切除术. 乳腺纤维瘤病由梭形细胞 (纤维母细胞/肌纤维母细胞) 构成, 背景是丰富的胶原纤维, 有程度不等的玻璃样变性. 细胞数量不等, 没有或仅有轻度的细胞不典型性和多形性, 核分裂象少见. 免疫组织化学染色5例vimentin均阳性, SMA均部分阳性, 3例β-catenin阳性, 而cytokeratin、 desmin、 EMA、 S-100和CD68均阴性. 结论乳腺纤维瘤病是一种罕见乳腺肿瘤, 呈进行性、侵袭性生长.
목적 탐토유선섬유류병적림상병리특정급감별진단요점. 방법 회고성분석5례유선섬유류병환자적림상자료병진행조직형태학、 면역조직화학연구, 대기림상표현、 병리형태특점급감별진단진행총결. 결과 5례균위녀성,발병년령24~75세, 평균년령53세. 3례행유선병조활검술, 2례행유선단순절제술. 유선섬유류병유사형세포 (섬유모세포/기섬유모세포) 구성, 배경시봉부적효원섬유, 유정도불등적파리양변성. 세포수량불등, 몰유혹부유경도적세포불전형성화다형성, 핵분렬상소견. 면역조직화학염색5례vimentin균양성, SMA균부분양성, 3례β-catenin양성, 이cytokeratin、 desmin、 EMA、 S-100화CD68균음성. 결론 유선섬유류병시일충한견유선종류, 정진행성、 침습성생장.
Objective To investigate the clinicopathological features and differential diagnosis of fibroma-tosis of the breast. Methods Five cases of breast fibromatosis were reviewed based on clinical, histomorphologi-cal, and immunohistochemical studies. Their clinical manifestations, pathologic features and main points of dif-ferential diagnosis were discussed. Results The 5 cases were all females, with age of onset ranging from 24 to 75 years and an average age of 53 years. Three cases underwent breast focal biopsy, and 2 cases underwent sim-ple mastectomy. Breast fibromatosis was composed of spindle cells ( fibroblasts/myofibroblasts) in a background of numerous thick and wavy collagen fibers, showing various degrees of hyaline degeneration. The cells varied in number, but all with absence or low degree of pleomorphism and hypercellularity, and scarcity of mitotic figures. According to immunohistochemical study, the 5 cases were all vimentin positive and SMA partly positive, 3 cases wereβ-catenin positive, while cytokeratin, desmin, EMA, S-100 and CD68 were negative. Conclusion Fibro-matosis of the breast is a rare breast tumor, developing in a progressive and invasive pattern.