CAJ | 학술논문

目的采用meta分析评价盐酸氢吗啡酮注射液治疗慢性疼痛的有效性.方法检索Web of Science Proceedings和PubMed数据库,无语种和发表时间限制.收集评价盐酸氢吗啡酮注射液治疗慢性疼痛有效性的临床研究.主要评价指标包括:VAS评分、疼痛控制率或缓解率等.由2名研究人员独立地筛选研究并提取数据,并利用Stata 10软件进行数据分析.结果最终共11项研究符合纳入标准,共452例患者.与治疗前比较,盐酸氢吗啡酮注射液治疗后VAS评分降低(P＜0.05).对于癌性疼痛患者,与其他阿片类镇痛药比较,盐酸氢吗啡酮注射液治疗后VAS评分降低,疼痛缓解率或控制率升高(P＜0.05).结论盐酸氢吗啡酮注射液可治疗慢性疼痛,其对癌性疼痛患者的治疗效果可能优于其他阿片类镇痛药物.
목적 채용meta분석평개염산경마배동주사액치료만성동통적유효성.방법 검색Web of Science Proceedings화PubMed수거고,무어충화발표시간한제.수집평개염산경마배동주사액치료만성동통유효성적림상연구.주요평개지표포괄:VAS평분、동통공제솔혹완해솔등.유2명연구인원독입지사선연구병제취수거,병이용Stata 10연건진행수거분석.결과 최종공11항연구부합납입표준,공452례환자.여치료전비교,염산경마배동주사액치료후VAS평분강저(P＜0.05).대우암성동통환자,여기타아편류진통약비교,염산경마배동주사액치료후VAS평분강저,동통완해솔혹공제솔승고(P＜0.05).결론 염산경마배동주사액가치료만성동통,기대암성동통환자적치료효과가능우우기타아편류진통약물.
Objective To systematically review the efficacy of hydromorphone hydrochloride injection for treatment of chronic pain.Methods Web of Science Proceedings and PubMed were searched for clinical trials involving the efficacy of hydromorphone for treatment of chronic pain, with no language or time limit.Evaluation indexes included visual analogue scale (VAS) score and the rate of pain control or relief.The studies were screened independently, and the data were extracted by two researchers.Meta-analysis was conducted using the Stata 10 software.Results Eleven studies involving 452 patients were included in our meta-analysis.VAS score was significantly decreased after treatment compared with that before treatment.For the patients with cancer pain, VAS score was significantly decreased after treatment with hydromorphone hydrochoride injection, and the rate of pain control or relief was increased when compared with the other opioid analgesics.Conclusion Hydromorphone hydrochloride injection can treat chronic pain, and it may provide better therapeutic effect than the other opioid analgesics for the patients with cancer pain.