中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
Chinese Journal of Experimental Surgery
2015年
11期
2818-2819
,共2页
星形细胞上调基因-1%Girdin%乳腺癌%免疫组织化学
星形細胞上調基因-1%Girdin%乳腺癌%免疫組織化學
성형세포상조기인-1%Girdin%유선암%면역조직화학
Astrocyte elevated gene-1%Girdin%Breast carcinoma%Immunohistochemistry
目的 探讨星形细胞上调基因-1(AEG-1)和Girdin在乳腺癌组织中的表达及与乳腺癌临床病理特征的关系.方法 利用免疫组织化学Envision法检测88例乳腺癌组织及相应癌旁组织中AEG-1和Girdin的表达水平.结果 AEG-1在乳腺癌组织中表达率明显高于癌旁组织(85.23％比15.91％,P＜0.01),AEG-1表达水平与乳腺癌肿瘤大小、TNM分期、淋巴结转移明显相关(P＜ 0.05);Girdin在乳腺癌组织中表达率明显高于癌旁组织(52.27％比12.50％,P＜0.01),Girdin表达水平与乳腺癌TNM分期、淋巴结转移明显相关(P＜0.05).结论 检测乳腺癌中AEG-1和Girdin表达水平可有助于预测乳腺癌的生物学行为.
目的 探討星形細胞上調基因-1(AEG-1)和Girdin在乳腺癌組織中的錶達及與乳腺癌臨床病理特徵的關繫.方法 利用免疫組織化學Envision法檢測88例乳腺癌組織及相應癌徬組織中AEG-1和Girdin的錶達水平.結果 AEG-1在乳腺癌組織中錶達率明顯高于癌徬組織(85.23％比15.91％,P＜0.01),AEG-1錶達水平與乳腺癌腫瘤大小、TNM分期、淋巴結轉移明顯相關(P＜ 0.05);Girdin在乳腺癌組織中錶達率明顯高于癌徬組織(52.27％比12.50％,P＜0.01),Girdin錶達水平與乳腺癌TNM分期、淋巴結轉移明顯相關(P＜0.05).結論 檢測乳腺癌中AEG-1和Girdin錶達水平可有助于預測乳腺癌的生物學行為.
목적 탐토성형세포상조기인-1(AEG-1)화Girdin재유선암조직중적표체급여유선암림상병리특정적관계.방법 이용면역조직화학Envision법검측88례유선암조직급상응암방조직중AEG-1화Girdin적표체수평.결과 AEG-1재유선암조직중표체솔명현고우암방조직(85.23％비15.91％,P＜0.01),AEG-1표체수평여유선암종류대소、TNM분기、림파결전이명현상관(P＜ 0.05);Girdin재유선암조직중표체솔명현고우암방조직(52.27％비12.50％,P＜0.01),Girdin표체수평여유선암TNM분기、림파결전이명현상관(P＜0.05).결론 검측유선암중AEG-1화Girdin표체수평가유조우예측유선암적생물학행위.
Objective To investigate the expression of astrocyte elevated gene-1 (AEG-1) and Girdin in breast carcinoma and its correlation with the clinicopathologic features.Methods The expression of AEG-1 and Girdin was detected by immunohistochemical Envision technique in 88 cases of breast carcinoma tissues and paired non-cancerous adjacent breast tissues.Results The expression rate of AEG-1 in breast carcinoma tissues was higher than that in the paired non-cancerous adjacent breast tissues (85.23％ vs.15.91％, P ＜0.01).The expression of AEG-1 was related breast carcinoma to tumor size, TNM stage and lymph node metastasis (P ＜ 0.05).The expression rate of Girdin in breast carcinoma tissues was higher than that in paired non-cancerous adjacent breast tissues (52.27％ vs.12.50％, P ＜ 0.01).The expression of Girdin was related breast carcinoma to TNM stage and lymph node metastasis (P ＜ 0.05).Conclusion The detection of AEG-1 and Girdin in the breast carcinoma may be helpful for predicting the biological behavior of the breast carcinoma.
