CAJ | 학술논문

目的探讨缺氧诱导因子-1α(HIF-1α)及缺氧诱导因子-2α(HIF-2α)在非小细胞肺癌肿瘤组织中的表达及临床意义.方法选择非小细胞肺癌患者51例的肺癌组织,采用免疫组织化学法检测肿瘤组织中HIF-1α和HIF-2α的表达,并分析其临床意义.结果 25例(49.0％)患者HIF-1α阳性,12例(23.5％)患者HIF-2α阳性.HIF-1α阳性表达与患者的年龄、性别、肿瘤最大直径、是否淋巴结转移、是否胸膜侵袭均无明显相关(P＞0.05).HIF-2α阳性表达与患者年龄、性别、是否淋巴结转移、是否胸膜侵袭亦无明显相关(P＞0.05);但是肿瘤最大径≥3 cm者阳性率显著高于直径＜3 cm者(P＜0.05).结论 HIF-1α及HIF-2α在非小细胞肺癌的肿瘤组织中呈阳性表达,而在癌旁组织中无明显表达,HIF-2α阳性率与肿瘤的最大直径有关.
목적 탐토결양유도인자-1α(HIF-1α)급결양유도인자-2α(HIF-2α)재비소세포폐암종류조직중적표체급림상의의.방법 선택비소세포폐암환자51례적폐암조직,채용면역조직화학법검측종류조직중HIF-1α화HIF-2α적표체,병분석기림상의의.결과 25례(49.0％)환자HIF-1α양성,12례(23.5％)환자HIF-2α양성.HIF-1α양성표체여환자적년령、성별、종류최대직경、시부림파결전이、시부흉막침습균무명현상관(P＞0.05).HIF-2α양성표체여환자년령、성별、시부림파결전이、시부흉막침습역무명현상관(P＞0.05);단시종류최대경≥3 cm자양성솔현저고우직경＜3 cm자(P＜0.05).결론 HIF-1α급HIF-2α재비소세포폐암적종류조직중정양성표체,이재암방조직중무명현표체,HIF-2α양성솔여종류적최대직경유관.
Objective To discuss the expression and clinical significance of hypoxia inducible factor-1α (HIF-1α) and hypoxia inducible factor-2α (HIF-2α) in non-small cell lung cancer tissues.Methods HIF-1α and HIF-2α expression in 51 cases of small cell lung cancer tissues was detected by immunohistochemistry, and clinical significance was analyzed.Results Twenty-five cases (49.0％) were positive for HIF-1α, and 12 cases (23.5％) were positive for HIF-2α in lung cancer tissues.HIF-1α expression had no correlation with age, gender, tumor size, lymph node metastasis and pleural invasion (P ＞ 0.05).HIF-2α expression had no correlation with age, gender, lymph node metastasis, pleural invasion (P ＞ 0.05).The positive rate of cases with maximum tumor diameter ≥3 cm was significantly higher than that in the cases with the diameter ＜ 3 cm (P ＜ 0.05).Conclusion HIF-1α and HIF-2α expression in small cell lung cancer tissues was positive.The HIF-2α positive rate is correlated with the maximum diameter of tumor.