中国全科医学
中國全科醫學
중국전과의학
Chinese General Practice
2015年
34期
4196-4201
,共6页
成年人%社区%盐敏感%高血压%影响因素分析
成年人%社區%鹽敏感%高血壓%影響因素分析
성년인%사구%염민감%고혈압%영향인소분석
Adult%Community%Salt-sensitivity%Hypertension%Root cause analysis
目的:探讨社区成年人盐敏感性高血压的影响因素。方法2013年12月—2014年4月,采用分层随机抽样法选取浙江省杭州市江干区闸弄口街道社区卫生服务中心辖区居民642例,进行问卷调查,并测量身高、体质量、腰围及血压,检测同型半胱氨酸、肾功能、血糖、血电解质、血脂、空腹胰岛素及尿电解质。采用改良Sullivan急性口服盐水负荷试验进行盐敏感性判定,将居民分为盐敏感性高血压组( n=36)与非盐敏感非高血压组( n=303),比较两组一般情况,采用多因素Logistic回归分析盐敏感性高血压的影响因素。结果642例居民中,共检出盐敏感者183例(28.5%);盐敏感人群中高血压患者36例(占19.7%)。盐敏感高血压组年龄、BMI、同型半胱氨酸、空腹胰岛素水平和父、母亲高血压患病率及服盐水后平均动脉压均高于非盐敏感非高血压组,服盐水前平均动脉压及服盐水后尿氯、尿钾水平均低于非盐敏感非高血压组,差异有统计学意义( P﹤0.05)。多因素Logistic回归分析显示,空腹胰岛素〔OR=0.11,95%CI(0.02,0.69)〕、同型半胱氨酸〔OR=4.92,95%CI(1.13,21.39)〕是盐敏感性高血压的影响因素(P﹤0.05)。结论空腹低胰岛素水平(﹤4.50 U/L)是盐敏感性高血压发生的保护因素,而血清高同型半胱氨酸水平(﹥15.0μmol/L)是盐敏感性高血压发生的危险因素。
目的:探討社區成年人鹽敏感性高血壓的影響因素。方法2013年12月—2014年4月,採用分層隨機抽樣法選取浙江省杭州市江榦區閘弄口街道社區衛生服務中心轄區居民642例,進行問捲調查,併測量身高、體質量、腰圍及血壓,檢測同型半胱氨痠、腎功能、血糖、血電解質、血脂、空腹胰島素及尿電解質。採用改良Sullivan急性口服鹽水負荷試驗進行鹽敏感性判定,將居民分為鹽敏感性高血壓組( n=36)與非鹽敏感非高血壓組( n=303),比較兩組一般情況,採用多因素Logistic迴歸分析鹽敏感性高血壓的影響因素。結果642例居民中,共檢齣鹽敏感者183例(28.5%);鹽敏感人群中高血壓患者36例(佔19.7%)。鹽敏感高血壓組年齡、BMI、同型半胱氨痠、空腹胰島素水平和父、母親高血壓患病率及服鹽水後平均動脈壓均高于非鹽敏感非高血壓組,服鹽水前平均動脈壓及服鹽水後尿氯、尿鉀水平均低于非鹽敏感非高血壓組,差異有統計學意義( P﹤0.05)。多因素Logistic迴歸分析顯示,空腹胰島素〔OR=0.11,95%CI(0.02,0.69)〕、同型半胱氨痠〔OR=4.92,95%CI(1.13,21.39)〕是鹽敏感性高血壓的影響因素(P﹤0.05)。結論空腹低胰島素水平(﹤4.50 U/L)是鹽敏感性高血壓髮生的保護因素,而血清高同型半胱氨痠水平(﹥15.0μmol/L)是鹽敏感性高血壓髮生的危險因素。
목적:탐토사구성년인염민감성고혈압적영향인소。방법2013년12월—2014년4월,채용분층수궤추양법선취절강성항주시강간구갑롱구가도사구위생복무중심할구거민642례,진행문권조사,병측량신고、체질량、요위급혈압,검측동형반광안산、신공능、혈당、혈전해질、혈지、공복이도소급뇨전해질。채용개량Sullivan급성구복염수부하시험진행염민감성판정,장거민분위염민감성고혈압조( n=36)여비염민감비고혈압조( n=303),비교량조일반정황,채용다인소Logistic회귀분석염민감성고혈압적영향인소。결과642례거민중,공검출염민감자183례(28.5%);염민감인군중고혈압환자36례(점19.7%)。염민감고혈압조년령、BMI、동형반광안산、공복이도소수평화부、모친고혈압환병솔급복염수후평균동맥압균고우비염민감비고혈압조,복염수전평균동맥압급복염수후뇨록、뇨갑수평균저우비염민감비고혈압조,차이유통계학의의( P﹤0.05)。다인소Logistic회귀분석현시,공복이도소〔OR=0.11,95%CI(0.02,0.69)〕、동형반광안산〔OR=4.92,95%CI(1.13,21.39)〕시염민감성고혈압적영향인소(P﹤0.05)。결론공복저이도소수평(﹤4.50 U/L)시염민감성고혈압발생적보호인소,이혈청고동형반광안산수평(﹥15.0μmol/L)시염민감성고혈압발생적위험인소。
Objective To explore the influencing factors for salt-sensitive hypertension in adults. Methods Using stratified random sampling method, we enrolled 642 residents from Zhalongkou Street Community Health Service Center of Jianggan District of Hangzhou in Zhejiang Province from December 2013 to April 2014. Questionnaire survey was conducted;height,body mass, waistline and blood pressure were measured;homocysteine, renal funciton, blood glucose, blood electrolytes,blood lipid,fasting insulin and urinary electrolytes were determined. Using an improved Sullivan's acute oral saline loading test,salt sensitivity was determined. Residents were divided into salt-sensitive hypertension group(n=36)and non-salt-sensitivity non-hypertension group(n=303). Comparison was made between the two groups in general information,and multivariate logistic regression analysis was undertaken to investigate the influencing factors for salt - sensitive hypertension. Results Among the 642 residents,we found salt sensitivity in 183(28. 5%)residents,of which 36(19. 7%) residents had hypertension. The salt-sensitive hypertension group was higher(P﹤0. 05)in age,BMI,homocysteine,fasting insulin level,prevalence of hypertension of parents and average arterial pressure after taking saline and were lower(P﹤0. 05)in the average arterial pressure before taking saline and the levels of urinary chlorine and urine potassium after taking saline than non-salt-sensitivity non -hypertension group. Multivariate logistic regression analysis showed that fasting insulin〔OR =0. 11, 95%CI(0. 02,0. 69)〕and homocysteine〔OR=4. 92,95%CI(1. 13,21. 39)〕were influencing factors for salt-sensitive hypertension(P﹤0. 05). Conclusion Low fasting insulin level( ﹤4. 50 U/L)is a protective factor for hypertension,while high serum homocysteine level( ﹥15. 0 μmol/L) is a risk factor for the occurrence of sensitive hypertension.