中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
Chinese Journal of Experimental Surgery
2015年
11期
2838-2840
,共3页
孙红绪%陈志芬%朱海珍%王淯溶%张弛%马翔%王小康%齐健%谢伟
孫紅緒%陳誌芬%硃海珍%王淯溶%張弛%馬翔%王小康%齊健%謝偉
손홍서%진지분%주해진%왕육용%장이%마상%왕소강%제건%사위
胃癌%热休克蛋白%ω-3多不饱和脂肪酸%炎症
胃癌%熱休剋蛋白%ω-3多不飽和脂肪痠%炎癥
위암%열휴극단백%ω-3다불포화지방산%염증
Gastric cancer%Heat shock proteins%Inflammation%ω-3 polyunsaturated fatty acid
目的 观察 ω-3多不饱和脂肪酸对胃癌手术患者热休克蛋白70(HSP70)、炎性反应及免疫状态的影响.方法 接受胃癌切除手术患者120例进入研究,实验组60例接受ω-3多不饱和脂肪酸补充的全胃肠外营养,对照组60例接受一般全胃肠外营养.7d后观察HSP70、肿瘤坏死因子-α(TNF-α)及CD4/CD8变化.结果 两组患者研究期间均未出现死亡及过敏等不良反应.外周血中CD4/CD8比值在实验组手术当日是1.57±0.42,用ω-3鱼油脂肪乳7d后是3.97±0.31,明显升高,差异有统计学意义(P＜0.05).外周血中TNF-α在实验组手术当日是(334.83 ±61.37) pg/mg;用ω-3鱼油脂肪乳7d后是(176.46±51.61) pg/mg,明显降低,差异有统计学意义(P＜0.05).外周血中HSP70在实验组手术当日是(4.19 ±0.56) g/L;用ω-3鱼油脂肪乳7d后是(19.13 ±3.17) g/L,明显升高,差异有统计学意义(P＜0.05).而对照组外周血中CD4/CD8比值、TNF-α及HSP70表达在手术前后无明显变化,差异无统计学意义(P＞0.05).结论 胃癌手术患者术后使用ω-3多不饱和脂肪酸可增加HSP70表达,减轻患者炎性反应,并改善患者免疫功能状态.
目的 觀察 ω-3多不飽和脂肪痠對胃癌手術患者熱休剋蛋白70(HSP70)、炎性反應及免疫狀態的影響.方法 接受胃癌切除手術患者120例進入研究,實驗組60例接受ω-3多不飽和脂肪痠補充的全胃腸外營養,對照組60例接受一般全胃腸外營養.7d後觀察HSP70、腫瘤壞死因子-α(TNF-α)及CD4/CD8變化.結果 兩組患者研究期間均未齣現死亡及過敏等不良反應.外週血中CD4/CD8比值在實驗組手術噹日是1.57±0.42,用ω-3魚油脂肪乳7d後是3.97±0.31,明顯升高,差異有統計學意義(P＜0.05).外週血中TNF-α在實驗組手術噹日是(334.83 ±61.37) pg/mg;用ω-3魚油脂肪乳7d後是(176.46±51.61) pg/mg,明顯降低,差異有統計學意義(P＜0.05).外週血中HSP70在實驗組手術噹日是(4.19 ±0.56) g/L;用ω-3魚油脂肪乳7d後是(19.13 ±3.17) g/L,明顯升高,差異有統計學意義(P＜0.05).而對照組外週血中CD4/CD8比值、TNF-α及HSP70錶達在手術前後無明顯變化,差異無統計學意義(P＞0.05).結論 胃癌手術患者術後使用ω-3多不飽和脂肪痠可增加HSP70錶達,減輕患者炎性反應,併改善患者免疫功能狀態.
목적 관찰 ω-3다불포화지방산대위암수술환자열휴극단백70(HSP70)、염성반응급면역상태적영향.방법 접수위암절제수술환자120례진입연구,실험조60례접수ω-3다불포화지방산보충적전위장외영양,대조조60례접수일반전위장외영양.7d후관찰HSP70、종류배사인자-α(TNF-α)급CD4/CD8변화.결과 량조환자연구기간균미출현사망급과민등불량반응.외주혈중CD4/CD8비치재실험조수술당일시1.57±0.42,용ω-3어유지방유7d후시3.97±0.31,명현승고,차이유통계학의의(P＜0.05).외주혈중TNF-α재실험조수술당일시(334.83 ±61.37) pg/mg;용ω-3어유지방유7d후시(176.46±51.61) pg/mg,명현강저,차이유통계학의의(P＜0.05).외주혈중HSP70재실험조수술당일시(4.19 ±0.56) g/L;용ω-3어유지방유7d후시(19.13 ±3.17) g/L,명현승고,차이유통계학의의(P＜0.05).이대조조외주혈중CD4/CD8비치、TNF-α급HSP70표체재수술전후무명현변화,차이무통계학의의(P＞0.05).결론 위암수술환자술후사용ω-3다불포화지방산가증가HSP70표체,감경환자염성반응,병개선환자면역공능상태.
Objective To evaluate the effect of ω-3 polyunsaturated fatty acid on heat shock protein 70 (HSP 70) and tumor necrosis factor-α (TNF-α) in gastric cancer patients after operation.Methods 120 gastric cancer patients after operation were randomly divided into two groups: the group of standard total parentaral nutrition (standard group, n =60) and the group of standard total parenteral nutrition with ω-3 polyunsaturated fatty acid (treatment group, n =60).HSP70, TNF-α and CD4/CD8 ratio were measured.Results HSP70 and CD4/CD8 ratio were significantly hingher in treatment group after ω-3 polyunsaturated fatty acid nutrition treatment for 7 days (P ＜ 0.05).TNF-α was significantly lower in treatment group after 7-day ω-3 polyunsaturated fatty acid nutrition treatment (P ＜ 0.05).However, there was no significant change in standard group (P ＞ 0.05).Conclusion ω-3 polyunsaturated fatty acid administration is well tolerated in surgical gastric cancer patients and is beneficial.These results indicate that ω-3 polyunsaturated fatty acid can directly attenuate pro-inflammatory cytokine release, and improve immune responsiveness.
